ArticleAtherosclerosis2015
Novel coronary heart disease risk factors at 60-64 years and life course socioeconomic position: the 1946 British birth cohort.
Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Socioeconomic status in childhood and C reactive protein in adulthood: a systematic review and meta-analysis.Journal of epidemiology and community health · 2017Pooled it
- Intergenerational social mobility and leisure-time physical activity in adulthood: a systematic review.Journal of epidemiology and community health · 2017Pooled it
- Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study).BMC medicine · 2025Article
- Adverse childhood experiences and the development of multimorbidity across adulthood-a national 70-year cohort study.Age and ageing · 2023Article
- Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation-Results From the 1946 British Birth Cohort.Frontiers in cardiovascular medicine · 2022Article
- C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women.Women's midlife health · 2020Article
- Multi-cohort study identifies social determinants of systemic inflammation over the life course.Nature communications · 2019Article
- Socioeconomic disadvantage across the life-course and oral health in older age: findings from a longitudinal study of older British men.Journal of public health (Oxford, England) · 2018Article
- Occupational and educational inequalities in exit from employment at older ages: evidence from seven prospective cohorts.Occupational and environmental medicine · 2018Article
- Association between life-course socioeconomic position and inflammatory biomarkers in older age: a nationally representative cohort study in Taiwan.BMC geriatrics · 2017Article
- Article
- Baby Boomers and Birth Certificates: Early-Life Socioeconomic Status and Cancer Risk in Adulthood.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Coronary Artery Bypass Graft Surgery Outcomes Following 6.5 Years: A Nested Case-control Study.International journal of preventive medicine · 2017Article
- From paediatrics to geriatrics: a life course perspective on the MRC National Survey of Health and Development.European journal of epidemiology · 2016Article
- Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Review
- Sedentary Lifestyle and High-Carbohydrate Intake are Associated with Low-Grade Chronic Inflammation in Post-Menopause: A Cross-sectional Study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2016Article
- Socioeconomic conditions across life related to multiple measures of the endocrine system in older adults: Longitudinal findings from a British birth cohort study.Social science & medicine (1982) · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Social disadvantage across the life course is associated with a greater risk of coronary heart disease (CHD) and with established CHD risk factors, but less is known about whether novel CHD risk factors show the same patterns. The Medical Research Council National Survey of Health and Development was used to investigate associations between occupational socioeconomic position during childhood, early adulthood and middle age and markers of inflammation (C-reactive protein, interleukin-6), endothelial function (E-selectin, tissue-plasminogen activator), adipocyte function (leptin, adiponectin) and pancreatic beta cell function (proinsulin) measured at 60-64 years. Life course models representing sensitive periods, accumulation of risk and social mobility were compared with a saturated model to ascertain the nature of the relationship between social class across the life course and each of these novel CHD risk factors. For interleukin-6 and leptin, low childhood socioeconomic position alone was associated with high risk factor levels at 60-64 years, while for C-reactive protein and proinsulin, cumulative effects of low socioeconomic position in both childhood and early adulthood were associated with higher (adverse) risk factor levels at 60-64 years. No associations were observed between socioeconomic position at any life period with either endothelial marker or adiponectin. Associations for C-reactive protein, interleukin-6, leptin and proinsulin were reduced considerably by adjustment for body mass index and, to a lesser extent, cigarette smoking. In conclusion, socioeconomic position in early life is an important determinant of several novel CHD risk factors. Body mass index may be an important mediator of these relationships.
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