Evidence map›Paper›PMID 25437293›Full record

ReviewRheumatic diseases clinics of North America2014

Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease.

Kimber Simmons, Aaron W Michels

Open access · greenAbstract readReview
In one paragraph

Review in Rheumatic diseases clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Regulatory T Cell Plasticity and Stability and Autoimmune Diseases.Clinical reviews in allergy & immunology · 2020
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kimber SimmonsDepartment of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 1775 Aurora Court, Aurora, CO 80045, USA.
Aaron W MichelsDepartment of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 1775 Aurora Court, Aurora, CO 80045, USA. Electronic address: Aaron.michels@ucdenver.edu.
University of Colorado Denver · US

Funding

Multiple Autoantigens/Multiple Epitopes of Type 1DMR01DK032083 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 1986 to 2025
$6.9M
Training Program in Diabetes ResearchT32DK063687 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Andrea Steck · 2002 to 2026
$5.2M
Small Molecules Targeting Allele Specific MHC Class II PresentationK08DK095995 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 2012 to 2016
$762k
NIDDK NIH HHS K08 DK095995NIDDK NIH HHS R01 DK032083NIDDK NIH HHS T32 DK063687
6 · The paper itself

Abstract

Type 1 diabetes (T1D) is a chronic autoimmune disorder resulting from immune-mediated destruction of insulin-producing beta cells within the pancreatic islets. Prediction of T1D is now possible, as having 2 or more islet autoantibodies confers a 100% risk of diabetes development. With the ability to predict disease development, clinical trials to prevent diabetes onset have been completed and are currently under way. This review focuses on the natural history, prediction, and prevention trials in T1D. We review the lessons learned from these attempts at preventing a chronic autoimmune disease and apply the paradigm from T1D prevention to other autoimmune disorders.

Indexed as

Diet TherapyAbataceptAntibodies, Monoclonal, HumanizedAutoantibodiesAutoimmune DiseasesDiabetes Mellitus, Type 1Disease ProgressionEarly Medical InterventionGenetic Predisposition to DiseaseHLA-D AntigensHumansHypoglycemic AgentsImmunoconjugatesImmunosuppressive AgentsInsulinIslets of LangerhansAbataceptAntibodies, Monoclonal, HumanizedAutoantibodiesHLA-D AntigensHypoglycemic AgentsImmunoconjugatesImmunosuppressive AgentsInsulinNiacinamideteplizumabVitamin B ComplexAutoantibodiesAutoimmunityImmune therapiesPreventionType 1 diabetes

Identifiers

PMID25437293
PMCPMC4250578
OpenAlexW2043778558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.