Evidence map›Paper›PMID 25437229›Full record

ReviewCurrent opinion in virology2014

Roseolovirus molecular biology: recent advances.

Laurie T Krug, Philip E Pellett

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laurie T KrugDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, United States.
Philip E PellettDepartment of Immunology and Microbiology, Wayne State University, Detroit, MI 48201, United States. Electronic address: ppellett@med.wayne.edu.

Funding

Uracil DNA glycosylases in herpesvirus pathogenesis and DNA mutationR21AI111129 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KRUG, LAURIE T, MCBRIDE, KEVIN MICHAEL · 2014 to 2015
$447k
Function of gammaherpesvirus ORF75 tegument proteinsR21AI097875 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KRUG, LAURIE T · 2012 to 2013
$427k
NIAID NIH HHS AI097875-01NIAID NIH HHS AI111129-01NIAID NIH HHS R21 AI097875NIAID NIH HHS R21 AI111129
6 · The paper itself

Abstract

Human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, and HHV-7) are classified within the roseolovirus genus of the betaherpesvirus subfamily. Most humans likely harbor at least two of these large DNA viruses, and 1% of humans harbor germline chromosomally integrated (ci) HHV-6A or HHV-6B genomes. Differences at the genetic level manifest as distinct biologic properties during infection and disease. We provide a brief synopsis of roseolovirus replication and highlight the unique properties of their lifecycle and what is known about the viral gene products that mediate these functions. In the nearly 30 years since their discovery, we have only begun to unlock the molecular strategies these highly evolved pathogens employ to establish and maintain chronic infections in humans.

Indexed as

Virus ReplicationDNA, ViralHerpesvirus 6, HumanHerpesvirus 7, HumanHumansViral ProteinsDNA, ViralViral Proteins

Identifiers

PMID25437229
PMCPMC4753783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.