ArticlePathogens (Basel, Switzerland)2013
An emerging tick-borne disease of humans is caused by a subset of strains with conserved genome structure.
Article in Pathogens (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Exploration of geographical population structure ofCurrent research in parasitology & vector-borne diseases · 2026Article
- TICKHUNTER: A Targeted Hybridization-Capture Sequencing Approach for the Detection and Characterization of Tick-borne Pathogens and Blood Meals.bioRxiv : the preprint server for biology · 2025Article
- Investigation of the Blood Microbiome in Horses With Fever of Unknown Origin.Veterinary medicine and science · 2025Article
- Generation of Population-Level Diversity inPathogens (Basel, Switzerland) · 2025Article
- Molecular detection of Anaplasma phagocytophilum in field-collected Haemaphysalis larvae in the Republic of Korea.Parasites & vectors · 2025Article
- Genomic characters ofEmerging microbes & infections · 2024Article
- Diversity ofAnimals : an open access journal from MDPI · 2024Article
- Genomic Characteristics of Emerging Intraerythrocytic Anaplasma capra and High Prevalence in Goats, China.Emerging infectious diseases · 2023Article
- Genomic analyses indicate the North American Ap-ha variant of the tick-vectored bacterium Anaplasma phagocytophilum was introduced from Europe.Parasites & vectors · 2023Article
- Helminths in Invasive Raccoons (Pathogens (Basel, Switzerland) · 2023Article
- A Disease Outbreak in Beef Cattle Associated withAnimals : an open access journal from MDPI · 2023Article
- Comparative Whole Genome Analysis of anPathogens (Basel, Switzerland) · 2022Article
- Biostatistical prediction of genes essential for growth of Anaplasma phagocytophilum in a human promyelocytic cell line using a random transposon mutant library.Pathogens and disease · 2021Article
- A new genetic approach to distinguish strains of Anaplasma phagocytophilum that appear not to cause human disease.Ticks and tick-borne diseases · 2021Article
- Epidemiological and Clinicopathological Features ofFrontiers in veterinary science · 2021Review
- Global Transcription Profiles ofFrontiers in veterinary science · 2020Article
- Mutational analysis of gene function in the Anaplasmataceae: Challenges and perspectives.Ticks and tick-borne diseases · 2019Article
- Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells.Molecular & cellular proteomics : MCP · 2015Article
- Lambs immunized with an inactivated variant of Anaplasma phagocytophilum.Acta veterinaria Scandinavica · 2015Article
- Opening the black box of Anaplasma phagocytophilum diversity: current situation and future perspectives.Frontiers in cellular and infection microbiology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The prevalence of tick-borne diseases is increasing worldwide. One such emerging disease is human anaplasmosis. The causative organism, Anaplasma phagocytophilum, is known to infect multiple animal species and cause human fatalities in the U.S., Europe and Asia. Although long known to infect ruminants, it is unclear why there are increasing numbers of human infections. We analyzed the genome sequences of strains infecting humans, animals and ticks from diverse geographic locations. Despite extensive variability amongst these strains, those infecting humans had conserved genome structure including the pfam01617 superfamily that encodes the major, neutralization-sensitive, surface antigen. These data provide potential targets to identify human-infective strains and have significance for understanding the selective pressures that lead to emergence of disease in new species.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.