Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain.

Kazuo Kasai, Yoshifumi Iwamaru, Kentaro Masujin, Morikazu Imamura, Shirou Mohri, Takashi Yokoyama

Open access · goldAbstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 43% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions.Prion · 2015
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kazuo KasaiPrion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. kakasai@affrc.go.jp.

Yoshifumi IwamaruPrion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. gan@affrc.go.jp.

Kentaro MasujinPrion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. masujin@affrc.go.jp.

Morikazu ImamuraPrion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. imamuram@affrc.go.jp.

Shirou MohriPrion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. shirou@affrc.go.jp.

Takashi YokoyamaPrion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. tyoko@affrc.go.jp.

National Institute of Animal Health · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathological prion protein, PrPSc, displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrPSc aggregates of mouse-adapted prion strains. We showed that small PrPSc aggregates, previously thought to be PK-sensitive, are resistant to PK digestion. Furthermore, we showed that small PrPSc aggregates of the Chandler scrapie strain have greater resistance to PK digestion and aggregation-denaturation than large PrPSc aggregates of this strain. We conclude that this strain consists of heterogeneous PrPSc.

Identifiers

PMID25436883

DOI10.3390/pathogens2010092

PMCPMC4235706

OpenAlexW2081849142

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.