Evidence map›Paper›PMID 25436820›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2014

Lost opportunities to reduce periconception HIV transmission: safer conception counseling by South African providers addresses perinatal but not sexual HIV transmission.

Lynn T Matthews, Cecilia Milford, Angela Kaida, Matthew J Ehrlich, Courtney Ng, Ross Greener, F N Mosery, Abigail Harrison, Christina Psaros, Steven A Safren and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Lynn T Matthews*Center for Global Health and Division of Infectious Disease, Massachusetts General Hospital, Boston, MA; †MatCH Research (Maternal, Adolescent and Child Health Research), Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa; ‡Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; §Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA; ‖Harvard Medical School, Boston, MA; ¶Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, RI; #Department of Psychiatry, Massachusetts General Hospital, Boston, MA; **Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; ††Department of Health Services, Policy, and Practice, School of Public Health, Brown University, Providence, RI; and ‡‡School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Cecilia Milford
Angela Kaida
Matthew J Ehrlich
Courtney Ng
Ross Greener
F N Mosery
Abigail Harrison
Christina Psaros
Steven A Safren
Francis Bajunirwe
Ira B Wilson
David R Bangsberg
Jennifer A Smit
University of the Witwatersrand · ZAHarvard University · USBrown University · USCambridge Health Alliance · USCenter for Global Health · USMassachusetts General Hospital · USMbarara University of Science and Technology · UGSimon Fraser University · CA

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Spatial Analysis CoreR24HD041020 · NICHD · BROWN UNIVERSITY · PI LOGAN, JOHN R · 2001 to 2016
$7.4M
Improving the diagnosis and treatment of medication adherence problems in HIVK24MH092242 · NIMH · BROWN UNIVERSITY · PI WILSON, IRA B · 2010 to 2014
$937k
Addressing psychosocial comorbidities in HIV treatment and preventionK24MH094214 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2011 to 2015
$858k
Periconception HIV risk reduction for HIV-discordant couples in UgandaK23MH095655 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2011 to 2015
$854k
Perinatal Depression, Stigma, Social Capital Utilization and PMTCT AdherenceK23MH096651 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PSAROS, CHRISTINA · 2012 to 2016
$843k
Mentoring Patient Oriented Adherence Research in UgandaK24MH087227 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BANGSBERG, DAVID ROY · 2009 to 2013
$776k
Assessing providers' reproductive counseling practice for South Africans with HIVR03HD072602 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2012 to 2013
$141k
NIAID NIH HHS P30 AI042853NIAID NIH HHS P30 AI060354NICHD NIH HHS R03 HD072602NICHD NIH HHS R03-HD072602NICHD NIH HHS R24 HD041020NIMH NIH HHS K23 MH095655NIMH NIH HHS K23 MH096651NIMH NIH HHS K23MH096651NIMH NIH HHS K24 MH087227NIMH NIH HHS K24 MH092242NIMH NIH HHS K24 MH094214NIMH NIH HHS K24MH094214NIMH NIH HHS K24MH87227
6 · The paper itself

Abstract

introductionSafer conception strategies create opportunities for HIV-serodiscordant couples to realize fertility goals and minimize periconception HIV transmission. Patient-provider communication about fertility goals is the first step in safer conception counseling.

methodsWe explored provider practices of assessing fertility intentions among HIV-infected men and women, attitudes toward people living with HIV (PLWH) having children, and knowledge and provision of safer conception advice. We conducted in-depth interviews (9 counselors, 15 nurses, 5 doctors) and focus group discussions (6 counselors, 7 professional nurses) in eThekwini District, South Africa. Data were translated, transcribed, and analyzed using content analysis with NVivo10 software.

resultsAmong 42 participants, median age was 41 (range, 28-60) years, 93% (39) were women, and median years worked in the clinic was 7 (range, 1-27). Some providers assessed women's, not men's, plans for having children at antiretroviral therapy initiation, to avoid fetal exposure to efavirenz. When conducted, reproductive counseling included CD4 cell count and HIV viral load assessment, advising mutual HIV status disclosure, and referral to another provider. Barriers to safer conception counseling included provider assumptions of HIV seroconcordance, low knowledge of safer conception strategies, personal feelings toward PLWH having children, and challenges to tailoring safer sex messages.

conclusionsProviders need information about HIV serodiscordance and safer conception strategies to move beyond discussing only perinatal transmission and maternal health for PLWH who choose to conceive. Safer conception counseling may be more feasible if the message is distilled to delaying conception attempts until the infected partner is on antiretroviral therapy. Designated and motivated nurse providers may be required to provide comprehensive safer conception counseling.

Indexed as

FertilizationSafe SexAdultAttitude to HealthBlack PeopleContraceptionFemaleFocus GroupsHealth PersonnelHIV InfectionsHIV SeropositivityHumansInfectious Disease Transmission, VerticalMaleMiddle AgedPregnancy

Identifiers

PMID25436820
PMCPMC4251914
OpenAlexW2001945470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.