Evidence map›Paper›PMID 25436585›Full record

ReviewBiomolecular concepts2013

The molecular biology of selenocysteine.

Jonathan N Gonzalez-Flores, Sumangala P Shetty, Aditi Dubey, Paul R Copeland

Open access · hybridAbstract readReview
In one paragraph

Review in Biomolecular concepts, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  11. Loss of seryl-tRNA synthetase (Journal of medical genetics · 2022
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan N Gonzalez-Flores
Sumangala P Shetty
Aditi Dubey
Paul R Copeland

Funding

Functional Analysis of SBP2 and Selenocysteine IncorporationR01GM077073 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI COPELAND, PAUL R · 2006 to 2022
$5.5M
Expanding The Genetic Code In YeastR01GM094833 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI COPELAND, PAUL R · 2010 to 2013
$1.2M
NIGMS NIH HHS GM077073NIGMS NIH HHS GM094833NIGMS NIH HHS R01 GM077073NIGMS NIH HHS R01 GM094833
6 · The paper itself

Abstract

Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop codon, UGA. Layered on top of the canonical translation elongation machinery is a set of factors that exist solely to incorporate this important amino acid. The mechanism by which this process occurs, put into the context of selenoprotein biology, is the focus of this review.

Indexed as

3' Untranslated RegionsAnimalsConserved SequenceGene Expression RegulationHumansNucleotide MotifsPeptide Elongation FactorsProtein BiosynthesisProtein Interaction Domains and MotifsRNA-Binding ProteinsSelenocysteineSelenoproteins3' Untranslated RegionsPeptide Elongation FactorsRNA-Binding ProteinsSelenocysteineselenocysteine insertion sequence binding protein, mammalianSelenoproteins

Identifiers

PMID25436585
PMCPMC4269102
OpenAlexW2081682798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.