ReviewBiomolecular concepts2013
The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?
Review in Biomolecular concepts, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation.The EMBO journal · 2024Article
- Controlling Much? Viral Control of Host Chromatin Dynamics.Annual review of virology · 2024Review
- Peptide diffusion in biomolecular condensates.Biophysical journal · 2024Article
- Intranuclear Nanoribbons for Selective Killing of Osteosarcoma Cells.Angewandte Chemie (International ed. in English) · 2022Article
- Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)].Environment international · 2021Article
- Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation.Cell reports · 2020Article
- Assemblies of d-Peptides for Targeting Cell Nucleolus.Bioconjugate chemistry · 2019Article
- Fluorescence microscopy image classification of 2D HeLa cells based on the CapsNet neural network.Medical & biological engineering & computing · 2019Article
- Review of the "X chromosome-nucleolus nexus" hypothesis of autoimmune diseases with an update explaining disruption of the nucleolus.Immunologic research · 2018Review
- RNAs as Proximity-Labeling Media for Identifying Nuclear Speckle Positions Relative to the Genome.iScience · 2018Article
- Rapid and Efficient FISH using Pre-Labeled Oligomer Probes.Scientific reports · 2018Article
- The long-range interaction map of ribosomal DNA arrays.PLoS genetics · 2018Article
- The redundancy of the mammalian heterochromatic compartment.Current opinion in genetics & development · 2016Review
- Donkey genome and insight into the imprinting of fast karyotype evolution.Scientific reports · 2015Article
- The dynamic nature and territory of transcriptional machinery in the bacterial chromosome.Frontiers in microbiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The nucleolus is a prominent nuclear structure that is the site of ribosomal RNA (rRNA) transcription, and hence ribosome biogenesis. Cellular demand for ribosomes, and hence rRNA, is tightly linked to cell growth and the rRNA makes up the majority of all the RNA within a cell. To fulfill the cellular demand for rRNA, the ribosomal RNA (rDNA) genes are amplified to high copy number and transcribed at very high rates. As such, understanding the rDNA has profound consequences for our comprehension of genome and transcriptional organization in cells. In this review, we address the question of whether the nucleolus is a raft adrift the sea of nuclear DNA, or actively contributes to genome organization. We present evidence supporting the idea that the nucleolus, and the rDNA contained therein, play more roles in the biology of the cell than simply ribosome biogenesis. We propose that the nucleolus and the rDNA are central factors in the spatial organization of the genome, and that rapid alterations in nucleolar structure in response to changing conditions manifest themselves in altered genomic structures that have functional consequences. Finally, we discuss some predictions that result from the nucleolus having a central role in nuclear organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.