ReviewCardiology in review
Consensus review of the treatment of cardiovascular disease in people with hemophilia A and B.
Review in Cardiology in review. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05804734 (Vitamin K Antagonist Versus Direct Oral Anticoagulant Treatments in Hemophilia), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin K Antagonist Versus Direct Oral Anticoagulant Treatments in Hemophilia
Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- Case Report: Successful concomitant surgical interventions for dilated ascending aorta and aortic valve insufficiency in a severe haemophilia A case.Frontiers in medicine · 2026Article
- Coronary Revascularization in Patients with Hemophilia and Acute Coronary Syndrome: Case Report and Brief Literature Review.Journal of clinical medicine · 2025Review
- Management of patients with congenital bleeding disorders and cardiac indications for antithrombotic therapy.European heart journal. Cardiovascular pharmacotherapy · 2025Review
- Percutaneous closure of a large atrial septal defect in a patient with severe haemophilia A.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024Article
- Debates Surrounding the Use of Antithrombotic Therapy in Hemophilic Patients with Cardiovascular Disease: Best Strategies to Minimize Severe Bleeding Risk.International journal of molecular sciences · 2024Review
- Atherosclerosis in Patients with Congenital Hemophilia: A Focus on Peripheral Artery Disease.Life (Basel, Switzerland) · 2023Review
- Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.Thrombosis and haemostasis · 2023Article
- How we manage cardiovascular disease in patients with hemophilia.Haematologica · 2023Review
- Antithrombotic Treatment in Patients With Hemophilia: an EHA-ISTH-EAHAD-ESO Clinical Practice Guidance.HemaSphere · 2023Article
- Internal carotid artery dissection in a patient with hemophilia A: a case report and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research priorities to transform the care of people with hemophilia.Expert review of hematology · 2023Article
- Cardiovascular Risk Scores among Asymptomatic Adults with Haemophilia.Arquivos brasileiros de cardiologia · 2023Article
- Gene therapy and cardiac surgery in a patient with hemophilia.JTCVS techniques · 2022Article
- Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension.Diagnostics (Basel, Switzerland) · 2022Review
- Acute coronary syndrome in patients with hemophilia: a delicate balancing act.Journal of thrombosis and thrombolysis · 2022Review
- Percutaneous Coronary Intervention for Acute Coronary Syndrome in a 44-Year-Old Man With Hemophilia A.Texas Heart Institute journal · 2022Article
- Cardiovascular disease in hereditary haemophilia: The challenges of longevity.British journal of haematology · 2022Review
- Current Therapeutic Approach to Atrial Fibrillation in Patients with Congenital Hemophilia.Journal of personalized medicine · 2022Review
- Left ventricular rotational abnormalities in hemophilia-insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study.Quantitative imaging in medicine and surgery · 2022Article
- Haemophilia in France: Modelisation of the Clinical Pathway for Patients.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With advances in care, increasing numbers of people with hemophilia (PWH) achieve near-normal life expectancies and present with typical age-related cardiovascular conditions. Evidence-based guidelines for medical or surgical management of cardiovascular conditions in individuals with hemophilia are limited. Published recommendations exist for the management of some common cardiovascular conditions (eg, ischemic heart disease, atrial fibrillation), but identifying optimal strategies for anticoagulant or antithrombotic therapy constitutes the primary challenge of managing nonoperative cardiovascular disease (CVD) in PWH. In general, as long as factor concentrates or other hemostatic therapies maintain adequate hemostasis, the recommended medical and surgical management of CVD in PWH parallels that in individuals without hemophilia. The presence of factor inhibitors complicates hemophilia management. Published outcomes of CVD treatment in PWH are similar to those in the general population. Specific knowledge about factor replacement, factor inhibitors, and disease-specific treatment distinguishes the cardiovascular care of PWH from similar care of individuals without this rare bleeding disorder. Furthermore, a multidisciplinary approach incorporating a hematologist with an onsite coagulation laboratory, ideally associated with a hemophilia treatment center, is integral to the management of CVD in PWH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.