ArticlePloS one2014
Decreases in molecular diffusion, perfusion fraction and perfusion-related diffusion in fibrotic livers: a prospective clinical intravoxel incoherent motion MR imaging study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- Oxygen Transport Impairment in the Failing Heart: A Histology-Image-Based Computational Analysis.Annals of biomedical engineering · 2026Article
- The role of number-of-excitations (NEX) for the usability of free-breathing acquired diffusion-derived 'vessel density' (DDVD) and slow diffusion coefficient (SDC) maps in separating liver cysts, hemangiomas, and solid masses with a focus on small lesions.Journal of gastrointestinal oncology · 2026Article
- Dynamics of spatiotemporal pharmacological models for hepatitis B virus infection under lamivudine and pegylated interferon alfa-2b therapies.BMC infectious diseases · 2026Article
- Towards Clinical Translation of Intravoxel Incoherent Motion MRI: Acquisition and Analysis Consensus Recommendations.Journal of magnetic resonance imaging : JMRI · 2026Article
- Toward Optimized Intravoxel Incoherent Motion (IVIM) and Compartmental T2 Mapping in Abdominal Organs.Magnetic resonance in medicine · 2026Article
- The impacts of time of echo and time of repetition on slow diffusion coefficient (SDC) measure and the potential age- and gender-related variations in liver and spleen SDC values: studies of healthy volunteers.Quantitative imaging in medicine and surgery · 2026Article
- Fast, Robust T2-IVIM Quantitative MRI With Distortion and Motion-Corrected Multi-Echo EPI.Magnetic resonance in medicine · 2026Article
- Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.Magnetic resonance in medicine · 2026Article
- A combination of MRI diffusion-derived vessel density (DDVD) and slow diffusion coefficient (SDC) can reliably diagnose liver hemangioma: a testing of three centers' data.Journal of gastrointestinal oncology · 2025Article
- Predictive intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters in the staging of fibrosis in hepatitis B patients.Polish journal of radiology · 2025Article
- [Expert consensus on MRI diagnosis of liver fibrosis in chronic hepatitis B (version 2023)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Imaging Phenotypes and Evolution of Hepatic Langerhans Cell Histiocytosis on CT/MRI: A Retrospective Study of Clinical Cases and Literature Review.Bioengineering (Basel, Switzerland) · 2023Article
- Liver parenchymal changes and association with cardiac magnetic resonance imaging findings in repaired tetralogy of Fallot: an intravoxel incoherent motion magnetic resonance imaging study.Pediatric radiology · 2022Article
- Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging.Scientific reports · 2021Article
- Intravoxel incoherent motion diffusion-weighted MRI for the characterization of inflammation in chronic liver disease.European radiology · 2021Article
- Quantified MRI and 25OH-VitD3 can be used as effective biomarkers for patients with neoadjuvant chemotherapy-induced liver injury in CRCLM?BMC cancer · 2020Observational
- Progress of intravoxel incoherent motion diffusion-weighted imaging in liver diseases.World journal of clinical cases · 2020Review
- Intravoxel incoherent motion diffusion-weighted imaging to differentiate hepatocellular carcinoma from intrahepatic cholangiocarcinoma.Scientific reports · 2020Article
- Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was aimed to determine whether pure molecular-based diffusion coefficient (D) and perfusion-related diffusion parameters (perfusion fraction f, perfusion-related diffusion coefficient D*) differ in healthy livers and fibrotic livers through intra-voxel incoherent motion (IVIM) MR imaging. MATERIAL AND
methods17 healthy volunteers and 34 patients with histopathologically confirmed liver fibrosis patients (stage 1 = 14, stage 2 = 8, stage 3 & 4 = 12, METAVIR grading) were included. Liver MR imaging was performed at 1.5-T. IVIM diffusion weighted imaging sequence was based on standard single-shot DW spin echo-planar imaging, with ten b values of 10, 20, 40, 60, 80, 100, 150, 200, 400, 800 sec/mm2 respectively. Pixel-wise realization and regions-of-interest based quantification of IVIM parameters were performed.
resultsD, f, and D* in healthy volunteer livers and patient livers were 1.096±0.155 vs 0.917±0.152 (10(-3) mm2/s, p = 0.0015), 0.164±0.021 vs 0.123±0.029 (p<0.0001), and 13.085±2.943 vs 9.423±1.737 (10(-3) mm2/s, p<0.0001) respectively, all significantly lower in fibrotic livers. As the fibrosis severity progressed, D, f, and D* values decreased, with a trend significant for f and D*.
conclusionFibrotic liver is associated with lower pure molecular diffusion, lower perfusion volume fraction, and lower perfusion-related diffusion. The decrease of f and D* in the liver is significantly associated liver fibrosis severity.
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