ArticleOncology letters2015
Tumor size predicts prognosis of head and neck synovial cell sarcoma.
Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- [Synovial sarcoma of the parotid gland: a case report].The Pan African medical journal · 2026Article
- From Stone to Unknown: Incidental Discovery of Oral Synovial Sarcoma in a Patient With a Renal Staghorn Stone.Cureus · 2025Article
- Biphasic Synovial Sarcoma of the Palatine Tonsil: A Case Report and Literature Review.Clinical case reports · 2025Article
- A Rare Case of Primary Laryngeal Synovial Sarcoma, Challenges in Diagnosis and Management in a Resource-Limited Setup: A Case Report.Case reports in otolaryngology · 2025Article
- Oncologic Outcomes in Patients with Localized, Primary Head and Neck Synovial Sarcoma.Cancers · 2024Article
- Synovial sarcoma in the prevertebral space can mimic malignant neurogenic neoplasm: Case report and literature review.Radiology case reports · 2023Article
- Engineering tumoral vascular leakiness with gold nanoparticles.Nature communications · 2023Article
- Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods.Frontiers in cell and developmental biology · 2022Review
- A case of a 22-year-old man with primary synovial sarcoma of the parapharyngeal space with anSAGE open medical case reports · 2022Article
- Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers.Nano-micro letters · 2021Article
- Long non-coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA-126/stromal cell-derived factor-1 regulation.Oncology letters · 2021Article
- Analysis of Extended Resection of Limb Soft Tissue Leiomyosarcoma.BioMed research international · 2021Article
- Primary Intraosseous Synovial Sarcoma in the Mandible.Case reports in oncological medicine · 2021Article
- Monophasic synovial sarcoma of the pyriform fossa.BMJ case reports · 2020Article
- Prognostic factors for laryngeal sarcoma and nomogram development for prediction: a retrospective study based on SEER database.Annals of translational medicine · 2020Article
- Synovial sarcoma of the floor of the mouth: a rare case report.BMC oral health · 2020Article
- Synovial sarcoma of the supraclavicular region causing a hemorrhagic shock.Clinical case reports · 2019Article
- Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy.Nature nanotechnology · 2019Article
- Synovial sarcoma of the maxillary sinus: an extremely rare case with excellent response to chemotherapy.OncoTargets and therapy · 2018Article
- Synovial Sarcoma of Oral Cavity-a Rare Case Report.Indian journal of surgical oncology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck synoviosarcoma (HNSS) is uncommon. To the best of our knowledge, the specific clinicopathological characteristics, treatment outcome and prognostic factors of HNSS were uninvestigated at the time of writing, so a meta-analysis was performed. An online data collection was carried out using PubMed and Google Scholar. Studies that reported primary HNSS and the treatment, follow-up time and outcome were chosen for the present study. In total, 93 cases from 26 studies were included for analysis. The study sample consisted of 55 males and 38 females and the median age was 32.1 years (range, 4-76 years). The median follow-up period was 62.1 months (range, 1-373 months). The tumor size was correlated with local recurrence and metastasis of HNSS, as well as with mortality (P=0.001, P<0.0001 and P<0.0001, respectively). The three-year, five-year and 10-year survival rates were 82.1, 80.4 and 78.2% for treatment with surgery alone, and 88.5, 85.5 and 82% for treatment with surgery plus radiotherapy, respectively. A significant tumor size-dependent difference was found between the overall survival (OS) rates (P<0.0001), as tumors that were >5.0 cm in diameter were associated with a worse OS rate (hazard ratio, 6.460; 95% confidence interval, 206-18.917; P=0.001). The tumor size was found to be an independent adverse prognostic factor for the OS of HNSS patients. In conclusion, surgical excision is a mainstream treatment of HNSS and post-operative adjuvant radiotherapy improves the OS rate of HNSS patients.
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