Evidence map›Paper›PMID 25435966›Full record

ArticleOncology letters2015

The expression of Wnt-1 inducible signaling pathway protein-2 in astrocytoma: Correlation between pathological grade and clinical outcome.

Gelei Xiao, Zhi Tang, Xianrui Yuan, Jian Yuan, Jie Zhao, Zhiping Zhang, Zhengwen He, Jingping Liu

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gelei XiaoThe Institute of Skull Base Surgery and Neurooncology at Hunan, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
Zhi TangDepartment of Neurosurgery, Hunan Provincial Tumor Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China.
Xianrui YuanThe Institute of Skull Base Surgery and Neurooncology at Hunan, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
Jian YuanThe Institute of Skull Base Surgery and Neurooncology at Hunan, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
Jie ZhaoThe Institute of Skull Base Surgery and Neurooncology at Hunan, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
Zhiping ZhangThe Institute of Skull Base Surgery and Neurooncology at Hunan, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
Zhengwen HeDepartment of Neurosurgery, Hunan Provincial Tumor Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China.
Jingping LiuThe Institute of Skull Base Surgery and Neurooncology at Hunan, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wnt-1 inducible signaling pathway protein-2 (WISP-2) is a member of the CCN family, which is critical for the control of cell morphology, motion, adhesion and other processes involved in tumorigenesis. The expression pattern and clinical significance of WISP-2 in astrocytomas remains unclear. In this study, reverse transcription-polymerase chain reaction was performed to systematically investigate the expression of WISP-2 in 47 astrocytoma tissues of different pathological grades and 10 normal brain tissues. The mRNA expression levels of WISP-2 in the astrocytoma tissues were observed to be significantly higher than those in the normal brain tissues. Furthermore, the upregulation of WISP-2 was found to be associated with astrocytomas of higher pathological grades. Subsequently, 154 astrocytoma and 15 normal brain tissues were analyzed using immunohistochemistry and similar results were obtained. Univariate and multivariate survival analyses were used to determine the correlations between WISP-2 expression and overall survival (OS) and progression-free survival (PFS). The results indicated that the expression of WISP-2 was found to negatively correlate with patient PFS and OS. These results demonstrated that the WISP-2 protein is involved in the pathogenesis and progression of human astrocytomas and may serve as a malignant biomarker of this disease.

Indexed as

astrocytomaoverall survivalprogression-free survivalWnt-1 inducible signaling pathway protein-2

Identifiers

PMID25435966
PMCPMC4246620
OpenAlexW2087504301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.