ArticleEcancermedicalscience2014
Perfusion CT is a valuable diagnostic method for prostate cancer: a prospective study of 94 patients.
Article in Ecancermedicalscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Effect of field of view variation on CTP assessment of infarct core and penumbra in acute ischemic stroke.Scientific reports · 2025Article
- Absence of prostate oedema obviates the need for delay between fiducial marker insertion and radiotherapy simulation.Journal of medical radiation sciences · 2020Article
- 4D perfusion CT of prostate cancer for image-guided radiotherapy planning: A proof of concept study.PloS one · 2019Article
- Assessment of prostate cancer with integrated CT-perfusion using a sector-wise approach.Turkish journal of urology · 2017Article
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8 authors.
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Abstract
purposeThe aim of this study is to assess the usefulness of perfusion computer tomography (pCT) in prostate cancer (PCa) diagnostics. MATERIALS AND
methods94 patients with biopsy-proven PCa were enrolled in the study. Dynamic pCT of the prostate gland was performed for 50 seconds after an intravenous injection of contrast medium. Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were computed in the suspected PCa area and in normal prostatic tissue.
resultsPCa was visible in pCT in 90 of the 94 examined patients as a focal peripheral CT enhancement. When PCa was located in the peripheral zone (PZ), it was visible on perfusion maps, mostly showing an early peak followed by wash-out. The average values of all perfusion parameters were higher for tumour than for normal prostate tissue (p < 0.000). BV and BF were dependent on tumour grade expressed by the Gleason score (GS). All PCa cases were divided into groups, according to histological grade, as low (GS ≤ 6), medium (GS = 7), and high (GS > 7). In high-grade PCa, the mean BF value was significantly higher (p = 0.001) than the mean value of BF low- and medium-grade PCa (p = 0.011). Similar results were obtained regarding the mean values of BV; the more aggressive the cancer grade, the higher the mean BV value (p = 0.04).
conclusionCT quantitative perfusion imaging allows PCa to be distinguished from normal prostate tissue. The highest values for BF and BV were observed in the most aggressive PCa grade.
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