Evidence map›Paper›PMID 25435812›Full record

ArticleCancer cell international2014

Role of BC040587 as a predictor of poor outcome in breast cancer.

Yayun Chi, Sheng Huang, Lin Yuan, Mengying Liu, Naisi Huang, Shuling Zhou, Bingqing Zhou, Jiong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  6. Review
  7. Article
  8. Review
  9. Review
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  11. Review
  12. Current Status of Long Non-Coding RNAs in Human Breast Cancer.International journal of molecular sciences · 2016
    Review
  13. LncRNAs and cancer.Oncology letters · 2016
    Article
  14. Article
  15. A brief review on long noncoding RNAs: a new paradigm in breast cancer pathogenesis, diagnosis and therapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yayun ChiBreast Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China.
Sheng HuangBreast Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China.
Lin YuanDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China.
Mengying LiuBreast Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China.
Naisi HuangBreast Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China.
Shuling ZhouDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China.
Bingqing ZhouDepartment of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032 China.
Jiong WuBreast Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032 China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China.

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
NCATS NIH HHS UL1 TR000142
6 · The paper itself

Abstract

backgroundAccumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found to be associated with poor survival of osteosarcoma patients. However, its role in breast cancer (BC) remains unknown. The aim of this study was to examine the expression pattern of BC040587 in BC and to evaluate its biological role and clinical significance in prediction of prognosis.

methodsExpression of BC040587 was analyzed in 20 pairs of BC cancer tissues and adjacent noncancerous tissues (ANCT), also in 151 BC tissues, 9 BC cell lines and one normal breast cell line by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Differences between groups were tested for significance using Student's t-test (two-tailed). Then we analyzed the potential relationship between BC040587 expression and clinic pathological features of BC patients. The correlation was analyzed by SPSS software.

resultsIt showed that BC040587 expression was down regulated both in BC samples and in BC cell lines compared with corresponding normal control. BC040587 expression was correlated with menopausal status (p = 0.040) and tumor differentiation (p = 0.035). The Kaplan-Meier survival curves indicated that the overall survival (OS) was significantly poor in low BC040587 expression BC patients (p = 0.023). Furthermore, expression of BC040587 was significantly associated with worse prognosis and was shown to be an independent prognostic marker breast cancer (p = 0.032). Our studies indicate that BC040587 may represent a new marker of prognosis in breast cancer.

conclusionOur studies indicate that BC040587 is significantly down-regulated in BC tissues and BC cell lines. BC040587 may represent a new marker of prognosis in breast cancer.

Indexed as

BC040587Breast cancerLong non-coding RNAPrognosisTumor suppressor

Identifiers

PMID25435812
PMCPMC4246536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.