Evidence map›Paper›PMID 25435631›Full record

ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2014

Hepatoprotective effect of Cymbopogon citratus aqueous extract against hydrogen peroxide-induced liver injury in male rats.

Saleh Muhammad Rahim, Ekhlass Muhi Taha, Muneef Saeb Al-janabi, Bushra Ismael Al-douri, Kumar Das Simon, Abd Gaffar Mazlan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. miR‑148a‑3p regulates alcoholic liver fibrosis through targeting ERBB3.International journal of molecular medicine · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice.Evidence-based complementary and alternative medicine : eCAM · 2017
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Saleh Muhammad RahimDept.of Biology, Faculty of Education, University of Tikrit, 34001Tikrit,Salah Aldeen, Iraq ; School of Environmental and Natural Resource Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, D.E., Malaysia.
Ekhlass Muhi TahaDept. of Chemistry, Faculty of Science for Women, University of Baghdad, Baghdad, Iraq.
Muneef Saeb Al-janabiDept.of Biology, Faculty of Education, University of Tikrit, 34001Tikrit,Salah Aldeen, Iraq.
Bushra Ismael Al-douriDept.of Biology, Faculty of Education, University of Tikrit, 34001Tikrit,Salah Aldeen, Iraq.
Kumar Das SimonSchool of Environmental and Natural Resource Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, D.E., Malaysia.
Abd Gaffar MazlanSchool of Environmental and Natural Resource Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, D.E., Malaysia.
University of Tikrit · IQNational University of Malaysia · MYUniversity of Baghdad · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCymbopogon citratus (Poaceae) a tropical perennial herb plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. This study aimed at evaluating the protective effects of C. citratus aqueous extract against liver injury induced by hydrogen peroxide (H2O2), in male rats. MATERIALS AND

methodsTwenty-five rats were randomly divided into five different groups of five animals in each group; (1) Control. (2) Received H2O2 (0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus (100 mg·kg(-1) b wt), vitamin C (250 mg·kg(-1) b wt) respectively. (5), was given C. citratus alone. The treatments were administered for 30 days. Blood samples were collected and serum was used for biochemical assay including liver enzymes activities, total protein, total bilirubin and malonaldehyde, glutathione in serum and liver homogenates. Liver was excised and routinely processed for histological examinations.

resultsC. citratus attenuated liver damage due to H2O2 administration as indicated by the significant reduction (p<0.05), in the elevated levels of ALT, AST, ALP, LDH, TB, and MDA in serum and liver homogenates; increase in TP and GSH levels in serum and liver homogenates; and improvement of liver histo-pathological changes. These effects of the extract were similar to that of vitamin C which used as antioxidant reference.

conclusionC. citratus could effectively ameliorate H2O2-induced oxidative stress and prevent liver injury in male rats.

Indexed as

AnimalsChemical and Drug Induced Liver InjuryCymbopogonGlutathioneHumansHydrogen PeroxideLiverMaleMalondialdehydeOxidative StressPlant ExtractsPlant LeavesProtective AgentsRatsRats, Sprague-DawleyGlutathioneHydrogen PeroxideMalondialdehydePlant ExtractsProtective AgentsCymbopogon citratusHistopathologyHydrogen peroxideLiver enzymesRatSerum proteinsVitamin C

Identifiers

PMID25435631
PMCPMC4202655
OpenAlexW2100307540

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.