Evidence map›Paper›PMID 25435482›Full record

ReviewCritical care clinics2015

Using what you get: dynamic physiologic signatures of critical illness.

Andre L Holder, Gilles Clermont

Abstract readReview
In one paragraph

Review in Critical care clinics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Building the future of ICU care: Is our digital foundation strong enough? A multicentre survey of Australian and New Zealand intensive care units.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Intelligent Clinical Decision Support.Sensors (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Systems Medicine-Complexity Within, Simplicity Without.Journal of healthcare informatics research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andre L HolderDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Gilles ClermontDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: clermontg@ccm.upmc.edu.
University of Pittsburgh · US

Funding

Predicting Patient Instability Noninvasively for Nursing Care-Two (PPINNC-2)R01NR013912 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AL-ZAITI, SALAH S, CLERMONT, GILLES · 2012 to 2025
$7.0M
Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
Heart-Lung Interactions &Cardiovascular InsufficiencyK24HL067181 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PINSKY, MICHAEL R · 2002 to 2011
$1.4M
NHLBI NIH HHS HL07820NHLBI NIH HHS HL67181NHLBI NIH HHS K24 HL067181NHLBI NIH HHS T32 HL007820NINR NIH HHS NR013912NINR NIH HHS R01 NR013912
6 · The paper itself

Abstract

The development and resolution of cardiopulmonary instability take time to become clinically apparent, and the treatments provided take time to have an impact. The characterization of dynamic changes in hemodynamic and metabolic variables is implicit in physiologic signatures. When primary variables are collected with high enough frequency to derive new variables, this data hierarchy can be used to develop physiologic signatures. The creation of physiologic signatures requires no new information; additional knowledge is extracted from data that already exist. It is possible to create physiologic signatures for each stage in the process of clinical decompensation and recovery to improve outcomes.

Indexed as

Cardiovascular DiseasesCritical CareCritical IllnessData Interpretation, StatisticalHemodynamicsHumansLung DiseasesMonitoring, PhysiologicCardiopulmonary instabilityData hierarchyFused parameterMachine learningPhysiologic signature

Identifiers

PMID25435482
PMCPMC4476532
OpenAlexW50059372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.