Evidence map›Paper›PMID 25435289›Full record

ReviewJournal of ethnopharmacology2015

Khat use and appetite: an overview and comparison of amphetamine, khat and cathinone.

Andrine M Lemieux, Bingshuo Li, Mustafa al'Absi

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Journal of ethnopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  15. Progress and Research Trends onFrontiers in pharmacology · 2021
    Article
  16. Coenzyme QHeliyon · 2020
    Article
  17. Article
  18. Association between qat chewing and dyslipidaemia among young males.Journal of Taibah University Medical Sciences · 2019
    Article
  19. Prevalence of dyslipidemia among students of a Yemeni University.Journal of Taibah University Medical Sciences · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrine M LemieuxUniversity of Minnesota Medical School Duluth Campus, Duluth, MN, USA.
Bingshuo LiUniversity of Minnesota Medical School Duluth Campus, Duluth, MN, USA; Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany.
Mustafa al'AbsiUniversity of Minnesota Medical School Duluth Campus, Duluth, MN, USA. Electronic address: malabsi@umn.edu.
University of Minnesota, Duluth · US

Funding

Stress, Appetite, and Smoking RelapseR01DA027232 · NIDA · UNIVERSITY OF MINNESOTA · PI AL'ABSI, MUSTAFA, LEE, DUSTIN CLARK · 2010 to 2025
$4.6M
Khat Research Program: Neurobehavioral Impact of Long-Term UseR21DA024626 · NIDA · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA · 2009 to 2010
$283k
Biobehavioral Mechanisms of Concurrent Tobacco and Khat*R03TW007219 · FIC · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA N · 2005 to 2007
$109k
FIC NIH HHS R03 TW007219FIC NIH HHS R03TW007219NIDA NIH HHS DA024626NIDA NIH HHS R01 DA027232NIDA NIH HHS R21 DA024626NIDA NIH HHS R21DA024626
6 · The paper itself

Abstract

ethnopharmacological relevanceTo understand the role of khat (Catha edulis) use on the aberrations in appetite and weight which are common comorbidities for khat and other amphetamine users. MATERIALS AND

methodsWe provide a comprehensive overview and conceptual summary of the historical cultural use of khat as a natural stimulant and describe the similarities and differences between cathinone (the main psychoactive constituent of khat) and amphetamine highlighting the limited literature on the neurophysiology of appetite and subsequent weight effects of khat.

resultsAnimal and some human studies indicate that khat produces appetite suppression, although little is known about mechanisms of this effect. Both direct and indirect effects of khat stem from multiple factors including behavioral, chemical and neurophysiological effects on appetite and metabolism. Classic and newly identified appetite hormones have not been explored sufficiently in the study of appetite and khat use. Unique methodological challenges and opportunities are encountered when examining effects of khat and cathinone including khat-specific medical comorbidities, unique route of administration, differential patterns of behavioral effects relative to amphetamines and the nascent state of our understanding of the neurobiology of this drug.

conclusionA considerable amount of work remains in the study of the appetite effects of khat chewing and outline a program of research that could inform our understanding of this natural amphetamine׳s appetite effects and help prepare health care workers for the unique health effects of this drug.

Indexed as

CathaPlant StemsAlkaloidsAmphetamineAnimalsAppetiteAppetite DepressantsHumansPlant ExtractsAlkaloidsAmphetamineAppetite DepressantscathinonePlant ExtractsAmphetamineAppetiteCathinoneHealthKhatWeight loss

Identifiers

PMID25435289
PMCPMC4281284
OpenAlexW1978152207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.