Evidence map›Paper›PMID 25435109›Full record

ReviewPediatric clinics of North America2015

Genetic and nongenetic risk factors for childhood cancer.

Logan G Spector, Nathan Pankratz, Erin L Marcotte

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Article
  12. Article
  13. A Population-Based Assessment of Cancer Risk in Children With VACTERL.American journal of medical genetics. Part A · 2026
    Article
  14. BMJ open · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Logan G SpectorDivision of Epidemiology/Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware Street, Southeast, Minneapolis, MN 55455, USA. Electronic address: spector@umn.edu.
Nathan PankratzDepartment of Lab Medicine and Pathology, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA.
Erin L MarcotteDivision of Epidemiology/Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware Street, Southeast, Minneapolis, MN 55455, USA.

Funding

Translational Pediatric Cancer Epidemiology Research Training GrantT32CA099936 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Logan G. Spector · 2004 to 2026
$5.1M
NCI NIH HHS T32 CA099936
6 · The paper itself

Abstract

The causes of childhood cancer have been systematically studied for decades, but apart from high-dose radiation and prior chemotherapy there are few strong external risk factors. However, inherent risk factors including birth weight, parental age, and congenital anomalies are consistently associated with most types of pediatric cancer. Recently the contribution of common genetic variation to etiology has come into focus through genome-wide association studies. These have highlighted genes not previously implicated in childhood cancers and have suggested that common variation explains a larger proportion of childhood cancers than adult. Rare variation and nonmendelian inheritance may also contribute to childhood cancer risk but have not been widely examined.

Indexed as

Genetic Predisposition to DiseaseChildChild, PreschoolFemaleHumansMaleNeoplasmsRisk FactorsCase-control studiesEpidemiologyEtiologyGenome-wide association studiesPediatric cancer

Identifiers

PMID25435109
PMCPMC4384439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.