ArticleAutonomic neuroscience : basic & clinical2015
Obesity-induced increases in sympathetic nerve activity: sex matters.
Article in Autonomic neuroscience : basic & clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- Sex-specific association between obesity and sympathetic nerve activity in HFpEF.American journal of physiology. Heart and circulatory physiology · 2026Article
- Impact of Gestational Weight Gain and Maternal Weight on Sympathetic Adaptations.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Association between visceral adipose tissue measured by deep neural network architecture and chronic kidney disease.Scientific reports · 2026Article
- Blunted baroreflex-mediated sympathoinhibition and vasodilation to countdown before exercise in young women compared to men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Sociodemographic and Health Determinants of Adipose Tissue Distribution in a Local Community from Eastern Poland: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- The impact of diet and sociodemographic factors on cardiovascular health among students at Chimborazo polytechnic high school and State University of Milagro.Frontiers in public health · 2025Article
- Effect of acute intranasal insulin administration on muscle sympathetic nerve activity in healthy young adults.American journal of physiology. Heart and circulatory physiology · 2024Article
- Sex differences in sympathetic activity and pulse wave velocity in adults with chronic kidney disease.American journal of physiology. Renal physiology · 2024Article
- Assessment of the Role of Endothelial and Vascular Smooth Muscle EGFR for Acute Blood Pressure Effects of Angiotensin II and Adrenergic Stimulation in Obese Mice.Biomedicines · 2023Article
- Leptin Increases: Physiological Roles in the Control of Sympathetic Nerve Activity, Energy Balance, and the Hypothalamic-Pituitary-Thyroid Axis.International journal of molecular sciences · 2023Review
- Visceral fat and attribute-based medicine in chronic kidney disease.Frontiers in endocrinology · 2023Review
- Glomerular hyperfiltration and hypertrophy: an evaluation of maximum values in pathological indicators to discriminate "diseased" from "normal".Frontiers in medicine · 2023Review
- Role of the Autonomic Nervous System in the Hemodynamic Response to Hyperinsulinemia-Implications for Obesity and Insulin Resistance.Current diabetes reports · 2022Review
- Interplay between baroreflex sensitivity, obesity and related cardiometabolic risk factors (Review).Experimental and therapeutic medicine · 2022Review
- Sex/Gender Differences in Obesity Prevalence, Comorbidities, and Treatment.Current obesity reports · 2021Review
- Sex determination geneeLife · 2021Article
- Preserved glycemic control and baroreflex efficacy in young adult hypertensive female obese Zucker rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice.Molecular metabolism · 2020Article
- Endogenous Chemerin from PVAT Amplifies Electrical Field-Stimulated Arterial Contraction: Use of the Chemerin Knockout Rat.International journal of molecular sciences · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Abundant evidence obtained largely from male human and animal subjects indicates that obesity increases sympathetic nerve activity (SNA), which contributes to hypertension development. However, recent studies that included women reported that the strong relationships between muscle SNA and waist circumference or body mass index (BMI) found in men are not present in overweight and obese women. A similar sex difference in the association between adiposity and hypertension development has been identified in animal models of obesity. In this brief review, we consider two possible mechanisms for this sex difference. First, visceral adiposity, leptin, insulin, and angiotensin II have been identified as potential culprits in obesity-induced sympathoexcitation in males. We explore if these factors wield the same impact in females. Second, we consider if sex differences in vascular reactivity to sympathetic activation contribute. Our survey of the literature suggests that premenopausal females may be able to resist obesity-induced sympathoexcitation and hypertension in part due to differences in adipose disposition as well as its muted inflammatory response and reduced production of pressor versus depressor components of the renin-angiotensin system. In addition, vascular responsiveness to increased SNA may be reduced. However, more importantly, we identify the urgent need for further study, not only of sex differences per se, but also of the mechanisms that may mediate these differences. This information is required not only to refine treatment options for obese premenopausal women but also to potentially reveal new therapeutic avenues in obese men and women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.