ArticleChemosphere2015
In utero bisphenol A concentration, metabolism, and global DNA methylation across matched placenta, kidney, and liver in the human fetus.
Article in Chemosphere, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review.Annals of global health · 2018Pooled it
- DNA methylation as a biomarker of prenatal exposures: current challenges and opportunities.Environmental epigenetics · 2026Review
- Maternal Exposure to Organochlorine Pesticides and Epigenetic Alterations in Unexplained Recurrent Miscarriage.Current medicinal chemistry · 2026Article
- Isosorbide as a Molecular Glass: New Insights into the Physicochemical Behavior of a Biobased Diol.Molecules (Basel, Switzerland) · 2025Article
- Periconception bisphenol and phthalate concentrations in women and men, time to pregnancy, and risk of miscarriage.Environmental research · 2025Article
- Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: A Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos.Environmental health perspectives · 2025Article
- The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine.Journal of nanobiotechnology · 2024Review
- Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration.Epigenomes · 2024Article
- Fetal bisphenol and phthalate exposure and early childhood growth in a New York City birth cohort.Environment international · 2024Article
- From womb to wellness: early environmental exposures, cord blood DNA methylation and disease origins.Epigenomics · 2024Review
- Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases.Journal of xenobiotics · 2023Review
- Review
- An Overview to Molecularly Imprinted Electrochemical Sensors for the Detection of Bisphenol A.Sensors (Basel, Switzerland) · 2023Review
- The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A.International journal of molecular sciences · 2023Article
- Probing prenatal bisphenol exposures and tissue-specific DNA methylation responses in cord blood, cord tissue, and placenta.Reproductive toxicology (Elmsford, N.Y.) · 2023Article
- The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease.Toxics · 2022Review
- Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study.Clinical epigenetics · 2022Article
- Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review.Journal of xenobiotics · 2022Review
- Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta†.Biology of reproduction · 2022Article
- Maternal Phthalate and Bisphenol Urine Concentrations during Pregnancy and Early Markers of Arterial Health in Children.Environmental health perspectives · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
While urine has been an easily accessible and feasible matrix for human biomonitoring, analytical measurements in internal tissues and organs can provide more accurate exposure assessments to understand disease etiology. This is especially important for the endocrine active compound, bisphenol A (BPA), where studies investigating internal doses at sensitive periods of human development are currently lacking. Herein, BPA concentrations, BPA-specific metabolizing enzyme gene expression, and global DNA methylation were characterized across three matched tissues from elective pregnancy terminations of 2nd trimester human fetuses: the placenta, liver, and kidney (N=12 each; N=36 total). Compared to liver (free: 0.54-50.5 ng g(-1)), BPA concentrations were lower in matched placenta (<0.05-25.4 ng g(-1)) and kidney (0.08-11.1 ng g(-1)) specimens. BPA-specific metabolism gene expression of GUSB, UGT2B15, STS, and SULT1A1 differed across each tissue type; however, conjugation and deconjugation expression patterns were similar across the fetus. Average LINE1 and CCGG global methylation were 58.3% and 59.2% in placenta, 79.5% and 66.4% in fetal liver, and 77.9% and 77.0% in fetal kidney, with significant tissue-specific DNA methylation differences in both LINE1 (p-value<0.001) and CCGG content (p-value<0.001). Total BPA concentrations were positively associated with global methylation for the placenta only using the LINE1 assay (p-value: 0.002), suggesting organ-specific biological effects after fetal exposure. Utilizing sensitive human clinical specimens, results are informative for BPA toxicokinetics and toxicodynamics assessment in the developing human fetus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.