Evidence map›Paper›PMID 25434013›Full record

ReviewAdvances in physiology education2014

Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle.

Kristin I Stanford, Laurie J Goodyear

Open access · greenAbstract readReview
In one paragraph

Review in Advances in physiology education, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 7 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 7 syntheses or guidelines pooled it, 336 citations in OpenAlex.

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  4. A Systematic Review ofMolecules (Basel, Switzerland) · 2022
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kristin I StanfordSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts kristin.stanford@joslin.harvard.edu.
Laurie J GoodyearSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital · USHarvard University · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Exercise Regulation of Glucose Homeostasis Administrative SupplementR01DK101043 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 2013 to 2026
$7.3M
EXERCISE AND SKELETAL MUSCLE SIGNALING MECHANISMSR01AR042238 · NIAMS · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 1997 to 2013
$4.2M
NIAMS NIH HHS R01-AR-42238NIDDK NIH HHS 5-P30-DK-36836NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK101043NIDDK NIH HHS R01-DK-101043
6 · The paper itself

Abstract

Exercise is a well-established tool to prevent and combat type 2 diabetes. Exercise improves whole body metabolic health in people with type 2 diabetes, and adaptations to skeletal muscle are essential for this improvement. An acute bout of exercise increases skeletal muscle glucose uptake, while chronic exercise training improves mitochondrial function, increases mitochondrial biogenesis, and increases the expression of glucose transporter proteins and numerous metabolic genes. This review focuses on the molecular mechanisms that mediate the effects of exercise to increase glucose uptake in skeletal muscle.

Indexed as

Adaptation, PhysiologicalDiabetes Mellitus, Type 2ExerciseGlucoseHumansMuscle, SkeletalGlucoseexercisetype 2 diabetes

Identifiers

PMID25434013
PMCPMC4315445
OpenAlexW2150922155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.