ReviewAdvances in physiology education2014
Aerobic exercise and other healthy lifestyle factors that influence vascular aging.
Review in Advances in physiology education, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03019146 (Exploring Time-efficient Strategies to Improve Fitness for Surgery in Older Adults), which is not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploring Time-efficient Strategies to Improve Fitness for Surgery in Older Adults
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Arterial stiffness adaptations to chronic resistance and aerobic exercise: a systematic review of exercise modalities.Frontiers in public health · 2025Pooled it
- Effects of high-intensity interval exercise on arterial stiffness in individuals at risk for cardiovascular disease: a meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- The acute effect of passively assisted trunk stretching on central arterial stiffness and blood pressure in middle-aged to older adults.European journal of applied physiology · 2024Trial
- An exploratory randomized sub-study of light-to-moderate intensity exercise on cognitive function, depression symptoms and inflammation in older adults with heart failure.Journal of psychosomatic research · 2020Trial
- All-Extremity Exercise Training Improves Arterial Stiffness in Older Adults.Medicine and science in sports and exercise · 2017Trial
- Trial
- Longer rest intervals do not attenuate the superior effects of accumulated exercise on arterial stiffness.European journal of applied physiology · 2015Trial
- Impact of cigarette smoking on cardiovascular function following high-intensity interval exercise in physically active smokers.European journal of applied physiology · 2026Article
- Exploring the relationship between reproductive aging, arterial stiffness, and cardiorespiratory fitness in women after menopause.Physiological reports · 2026Article
- Preliminary effects and feasibility of a school-based regular aerobic exercise intervention on PTSD-related symptoms among college students: a single-group pre-post study.Frontiers in public health · 2026Article
- Molecular Drivers of Vascular Adaptation in Young Athletes: An Integrative Analysis of Endothelial, Metabolic and Lipoprotein Biomarkers.Biomolecules · 2025Article
- Exercise to Mitigate Premature Vascular Aging After Doxorubicin Breast Cancer Therapy.Exercise and sport sciences reviews · 2025Review
- Exploring Individual Factors Affecting Endothelial Function Response Variability in Aging: Implications for Precision Nutrition.Nutrients · 2025Review
- Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function.Biomolecules · 2025Review
- Active futures: combating youth sedentary lifestyles in Pakistan through smart use of fragmented time.Frontiers in sports and active living · 2025Article
- High-resistance inspiratory muscle strength training: a promising strategy for improving vascular health in chronic kidney disease.Frontiers in physiology · 2025Article
- Mechanical signaling regulates vascular smooth muscle cell adaptation in aging.Frontiers in physiology · 2025Article
- Aerobic Exercise Practiced Over Time Mitigates the Structural Effects on the Vascular System Caused by the Deleterious Effects of Aging.Vascular health and risk management · 2025Article
- Identification of differentially expressed miRNAs involved in vascular aging reveals pathways associated with the endocrine hormone regulation.Biogerontology · 2024Article
- Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Older Veterans: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular diseases (CVDs) remain the leading cause of death in the United States and other modern societies. Advancing age is the major risk factor for CVD, primarily due to stiffening of the large elastic arteries and the development of vascular endothelial dysfunction. In contrast, regular aerobic exercise protects against the development of large elastic artery stiffness and vascular endothelial dysfunction with advancing age. Moreover, aerobic exercise interventions reduce arterial stiffness and restore vascular endothelial function in previously sedentary middle-aged/older adults. Aerobic exercise exerts its beneficial effects on arterial function by modulating structural proteins, reducing oxidative stress and inflammation, and restoring nitric oxide bioavailability. Aerobic exercise may also promote "resistance" against factors that reduce vascular function and increase CVD risk with age. Preventing excessive increases in abdominal adiposity, following healthy dietary practices, maintaining a low CVD risk factor profile, and, possibly, selective use of pharmaceuticals and nutraceuticals also play a major role in preserving vascular function with aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.