Evidence map›Paper›PMID 25433798›Full record

ArticleBMC microbiology2014

An ontology for microbial phenotypes.

Marcus C Chibucos, Adrienne E Zweifel, Jonathan C Herrera, William Meza, Shabnam Eslamfam, Peter Uetz, Deborah A Siegele, James C Hu, Michelle G Giglio

Abstract read
In one paragraph

Article in BMC microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. OHMI: the ontology of host-microbiome interactions.Journal of biomedical semantics · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcus C ChibucosInstitute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. mchibucos@som.umaryland.edu.
Adrienne E ZweifelDepartment of Biochemistry and Biophysics, Texas A&M University and Texas AgriLife Research, College Station, TX, USA. adrienne.zweifel@ucsf.edu.
Jonathan C HerreraDepartment of Biology, Texas A&M University, College Station, TX, USA. jherrera@bio.tamu.edu.
William MezaDepartment of Biology, Texas A&M University, College Station, TX, USA. wmeza@bio.tamu.edu.
Shabnam EslamfamDepartment of Biochemistry and Biophysics, Texas A&M University and Texas AgriLife Research, College Station, TX, USA. shabnam127@hotmail.com.
Peter UetzVirginia Commonwealth University, Richmond, VA, USA. phuetz@vcu.edu.
Deborah A SiegeleDepartment of Biology, Texas A&M University, College Station, TX, USA. d-siegele@tamu.edu.
James C HuDepartment of Biochemistry and Biophysics, Texas A&M University and Texas AgriLife Research, College Station, TX, USA. jimhu@tamu.edu.
Michelle G GiglioInstitute for Genome Sciences and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. mgiglio@som.umaryland.edu.

Funding

An Ontology for Microbial PhenotypesR01GM089636 · NIGMS · TEXAS A&M UNIVERSITY · PI HU, JAMES C · 2010 to 2016
$1.6M
THE MECHANISM OF THE GROUP-TRANSFER PROCESSR01GM008963 · NIGMS · PURDUE UNIVERSITY WEST LAFAYETTE · PI RAY, WILLIAM J · 1985 to 1998
–
NIGMS NIH HHS R01 GM08963NIGMS NIH HHS R01 GM089636
6 · The paper itself

Abstract

backgroundPhenotypic data are routinely used to elucidate gene function in organisms amenable to genetic manipulation. However, previous to this work, there was no generalizable system in place for the structured storage and retrieval of phenotypic information for bacteria.

resultsThe Ontology of Microbial Phenotypes (OMP) has been created to standardize the capture of such phenotypic information from microbes. OMP has been built on the foundations of the Basic Formal Ontology and the Phenotype and Trait Ontology. Terms have logical definitions that can facilitate computational searching of phenotypes and their associated genes. OMP can be accessed via a wiki page as well as downloaded from SourceForge. Initial annotations with OMP are being made for Escherichia coli using a wiki-based annotation capture system. New OMP terms are being concurrently developed as annotation proceeds.

conclusionsWe anticipate that diverse groups studying microbial genetics and associated phenotypes will employ OMP for standardizing microbial phenotype annotation, much as the Gene Ontology has standardized gene product annotation. The resulting OMP resource and associated annotations will facilitate prediction of phenotypes for unknown genes and result in new experimental characterization of phenotypes and functions.

Indexed as

Bacterial Physiological PhenomenaSoftwareComputational BiologyPhenotype

Identifiers

PMID25433798
PMCPMC4287307

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.