ArticleAIDS and behavior2015
Comparison of pharmacy-based measures of adherence to antiretroviral therapy as predictors of virological failure.
Article in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Retention in a low-resource, high-burden South African cohort on antiretroviral therapy: Retrospective, longitudinal analysis comparing six measures of retention.Journal of the International AIDS Society · 2025Article
- Measuring patient engagement with HIV care in sub-Saharan Africa: a scoping study.Journal of the International AIDS Society · 2022Review
- Factors affecting optimal adherence to antiretroviral therapy and viral suppression amongst HIV-infected prisoners in South Ethiopia: a comparative cross-sectional study.AIDS research and therapy · 2022Article
- Pharmacy Refill Data are Poor Predictors of Virologic Treatment Outcomes in Adolescents with HIV in Botswana.AIDS and behavior · 2019Article
- The Association of Material Hardship with Medication Adherence and Perceived Stress Among People Living with HIV in Rural Zambia.Global social welfare : research, policy & practice · 2019Article
- Article
- Barriers and facilitators of antiretroviral therapy adherence in rural Eastern province, Zambia: the role of household economic status.African journal of AIDS research : AJAR · 2017Article
- Effect of pregnancy and the postpartum period on adherence to antiretroviral therapy among HIV-infected women established on treatment.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Comparative Analysis of two Methods of Measuring Antiretroviral Therapy Adherence in HIV-Infected Omani Patients.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We compared multiple pharmacy refill-based adherence indicators for antiretroviral therapy, as well as thresholds for defining non-adherent behavior, based on ability to predict virological failure. A total of 29,937 pharmacy visits with corresponding viral load assessments were contributed by 8,695 patients attending a large clinic in Johannesburg, South Africa. Indicators based on pill coverage and timing of refill pickup performed comparably using the strictest thresholds for adherence [100 % pill coverage: odds ratio (OR) (95 % confidence interval (CI)) : 1.26 (1.15, 1.39); prescription picked up on or before scheduled refill date: 1.27 (1.16,1.38)]. For both types of indicators, the association between non-adherence and virological failure increased as the threshold defining adherent behavior was lowered. All measures demonstrated high specificity (range 84-98 %), but low sensitivity (5-19 %). In this setting, patients identified as non-adherent using pharmacy-based indicators are likely correctly classified and in need of interventions to improve compliance. Pharmacy based measures alone, however, are inadequate for identifying most cases of nonadherence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.