Evidence map›Paper›PMID 25433519›Full record

SynthesisBMC neurology2014

Symptom changes in multiple sclerosis following psychological interventions: a systematic review.

Francesco Pagnini, Colin M Bosma, Deborah Phillips, Ellen Langer

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in BMC neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03825055 (Behaviour and Well-Being), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03825055 completednot on this mapstarted 2019, after this paper: background citation

Behaviour and Well-Being: A Bio-Psycho-Social Model of Resilience in Young Adults Newly Diagnosed With Multiple Sclerosis

TypeobservationalSponsorUniversita di VeronaRan2019 to 2022Enrolled51ConditionsMultiple Sclerosis
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Psychobiological Factors in Global Health and Public Health.International journal of environmental research and public health · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Longitudinal associations between mindfulness and well-being in people with multiple sclerosis.International journal of clinical and health psychology : IJCHP · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Francesco PagniniDepartment of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy. francesco.pagnini@unicatt.it.
Colin M BosmaDepartment of Psychology, Harvard University, Cambridge, MA, USA. bosma.colin@gmail.com.
Deborah PhillipsDepartment of Psychology, Harvard University, Cambridge, MA, USA. drp0125@gmail.com.
Ellen LangerDepartment of Psychology, Harvard University, Cambridge, MA, USA. langer@wjh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple Sclerosis is a disease of the central nervous system involving a variety of debilitating physical, sensory, cognitive and emotional symptoms. This literature review evaluated the impact of psychological interventions on the physiological symptoms associated with the illness.

methodsA systematic literature search was conducted using Medline, PsycINFO, Scopus, and the Cochrane Library databases, as well as reference lists. Relevant studies were selected and assessed according to a preset protocol.

resultsThe search produced 220 articles, with 22 meeting inclusion criteria for the review. A total of 5,705 subjects with Multiple Sclerosis were analyzed. Results from the included studies indicate a general improvement in both psychological and physiological outcomes following psychological treatment. The most highly influenced physical symptoms include fatigue, sleep disturbances, pain, and physical vitality.

conclusionsFindings from the review suggest a positive relationship between psychological interventions and physiological Multiple Sclerosis symptoms. Implications for future research are discussed.

Indexed as

FatigueHumansMultiple SclerosisSleep Wake Disorders

Identifiers

PMID25433519
PMCPMC4253984

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.