Evidence map›Paper›PMID 25433219›Full record

Trial reportArchives of physical medicine and rehabilitation2015

Improved cognitive performance following aerobic exercise training in people with traumatic brain injury.

Lisa M Chin, Randall Eugene Keyser, John Dsurney, Leighton Chan

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of physical medicine and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02504866 (Effect of Exercise Training on Physical, Cognitive and Behavioral Function in Patients With Traumatic Brain Injury), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02504866 naterminatednot on this mapstarted 2016, after this paper: background citation

Effect of Exercise Training on Physical, Cognitive and Behavioral Function in Patients With Traumatic Brain Injury

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2016 to 2020Enrolled20ConditionsTraumatic Brain Injury (TBI)ArmsVigorous exercise, Light to moderate exercise
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  16. Non-pharmacological interventions for traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lisa M ChinDepartment of Rehabilitation Science, George Mason University, Fairfax, VA; Rehabilitation Medicine Department, National Institutes of Health, Clinical Center, Bethesda, MD. Electronic address: lchin2@gmu.edu.
Randall Eugene KeyserDepartment of Rehabilitation Science, George Mason University, Fairfax, VA; Rehabilitation Medicine Department, National Institutes of Health, Clinical Center, Bethesda, MD.
John DsurneyRehabilitation Medicine Department, National Institutes of Health, Clinical Center, Bethesda, MD; Center for Neuroscience and Regenerative Medicine, Bethesda, MD.
Leighton ChanRehabilitation Medicine Department, National Institutes of Health, Clinical Center, Bethesda, MD; Center for Neuroscience and Regenerative Medicine, Bethesda, MD.

Funding

Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

objectiveTo examine cognitive function in individuals with traumatic brain injury (TBI) prior to and after participation in an aerobic exercise training program.

designPre-post intervention study.

settingMedical research center.

participantsVolunteer sample of individuals (N=7) (age, 33.3±7.9y) with chronic nonpenetrating TBI (injury severity: 3=mild, 4=moderate; time since most current injury: 4.0±5.5y) who were ambulatory.

interventionTwelve weeks of supervised vigorous aerobic exercise training performed 3 times a week for 30 minutes on a treadmill.

main outcome measuresCognitive function was assessed using the Trail Making Test Part A (TMT-A), Trail Making Test Part B (TMT-B), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sleep quality and depression were measured with the Pittsburgh Sleep Quality Index (PSQI) and Beck Depression Inventory, version 2 (BDI-II). Indices of cardiorespiratory fitness were used to examine the relation between improvements in cognitive function and cardiorespiratory fitness.

resultsAfter training, improvements in cognitive function were observed with greater scores on the TMT-A (10.3±6.8; P=.007), TMT-B (9.6±7.0; P=.011), and RBANS total scale (13.3±9.3; P=.009). No changes were observed in measures of the PSQI and BDI-II. The magnitude of cognitive improvements was also strongly related to the gains in cardiorespiratory fitness.

conclusionsThese findings suggest that vigorous aerobic exercise training may improve specific aspects of cognitive function in individuals with TBI and cardiorespiratory fitness gains may be a determinant of these improvements.

Indexed as

CognitionAdultBrain InjuriesDepressionExerciseExercise TherapyFemaleHumansMaleNeuropsychological TestsPhysical FitnessSleepTrauma Severity IndicesBrain injuriesCognitionExerciseNeuropsychological testsQuestionnairesRehabilitation

Identifiers

PMID25433219
PMCPMC4380661

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.