ArticleJournal of neurology, neurosurgery, and psychiatry2015
Disrupted small world topology and modular organisation of functional networks in late-life depression with and without amnestic mild cognitive impairment.
Article in Journal of neurology, neurosurgery, and psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disordersJournal of psychiatry & neuroscience : JPN · 2018Pooled it
- Spacetime in the brain: rapid brain network reorganization in visual processing and recovery.Scientific reports · 2021Trial
- Focal application of accelerated iTBS results in global changes in graph measures.Human brain mapping · 2019Trial
- Structural Alterations and Cognitive Impairment in Late-Onset Depression: A Reverse Correlation Analysis.Alpha psychiatry · 2026Article
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- Increasing variance of rich-club nodes distribution in early onset depression according to dynamic network.Brain imaging and behavior · 2024Article
- Disrupted topological organization of the default mode network in mild cognitive impairment with subsyndromal depression: A graph theoretical analysis.CNS neuroscience & therapeutics · 2024Article
- Article
- IMOVE: Protocol for a randomized, controlled 2x2 factorial trial of improvisational movement and social engagement interventions in older adults with early Alzheimer's disease.Contemporary clinical trials communications · 2023Article
- Association of functional connectivity of the executive control network or default mode network with cognitive impairment in older adults with remitted major depressive disorder or mild cognitive impairment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment.Frontiers in aging neuroscience · 2023Article
- Structural alterations of the insula in depression patients - A 7-Tesla-MRI study.NeuroImage. Clinical · 2022Article
- Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus.Frontiers in neuroscience · 2022Article
- Network Reconfiguration Among Cerebellar Visual,Frontiers in aging neuroscience · 2022Article
- Effect of SSRIs on Resting-State Functional Brain Networks in Adolescents with Major Depressive Disorder.Journal of clinical medicine · 2021Article
- Different Modular Organization Between Early Onset and Late Onset Depression: A Study Base on Granger Causality Analysis.Frontiers in aging neuroscience · 2021Article
- Frontal-executive and corticolimbic structural brain circuitry in older people with remitted depression, mild cognitive impairment, Alzheimer's dementia, and normal cognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Structural connectome alterations in patients with disorders of consciousness revealed by 7-tesla magnetic resonance imaging.NeuroImage. Clinical · 2019Article
- Structural and Functional Disruptions in Subcortical Vascular Mild Cognitive Impairment With and Without Depressive Symptoms.Frontiers in aging neuroscience · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe topological architecture of the whole-brain functional networks in those with and without late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are unknown.
aimsTo investigate the differences in the small-world measures and the modular community structure of the functional networks between patients with LLD and aMCI when occurring alone or in combination and cognitively healthy non-depressed controls.
methods79 elderly participants (LLD (n=23), aMCI (n=18), comorbid LLD and aMCI (n=13), and controls (n=25)) completed neuropsychiatric assessments. Graph theoretical methods were employed on resting-state functional connectivity MRI data.
resultsLLD and aMCI comorbidity was associated with the greatest disruptions in functional integration measures (decreased global efficiency and increased path length); both LLD groups showed abnormal functional segregation (reduced local efficiency). The modular network organisation was most variable in the comorbid group, followed by patients with LLD-only. Decreased mean global, local and nodal efficiency metrics were associated with greater depressive symptom severity but not memory performance.
conclusionsConsidering the whole brain as a complex network may provide unique insights on the neurobiological underpinnings of LLD with and without cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.