Evidence map›Paper›PMID 25432986›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2015

Enhanced infarct myocardium repair mediated by thermosensitive copolymer hydrogel-based stem cell transplantation.

Yu Xia, Kai Zhu, Hao Lai, Meidong Lang, Yan Xiao, Sheng Lian, Changfa Guo, Chunsheng Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases.Frontiers in bioengineering and biotechnology · 2020
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yu XiaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China Department of Cardio-Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, P. R. China.
Kai ZhuDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China.
Hao LaiDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China.
Meidong LangKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Yan XiaoKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Sheng LianKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Changfa GuoDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China guo.changfa@zs-hospital.sh.cn wang.chunsheng@zs-hospital.sh.cn.
Chunsheng WangDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China guo.changfa@zs-hospital.sh.cn wang.chunsheng@zs-hospital.sh.cn.
East China University of Science and Technology · CNFudan University · CNSun Yat-sen University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(ɛ-caprolactone) ratio of 88:9.6:2.4 was bioconjugated with type I collagen to construct a novel injectable thermosensitive hydrogel. The injectable and biocompatible hydrogel-mediated MSC transplantation could enhance the grafted cell survival in the myocardium, which contributed to the increased neovascularization, decreased interstitial fibrosis, and ultimately improved heart function to a significantly greater degree than regular MSC transplantation. We suggest that this novel hydrogel has the potential for future stem cell transplantation.

Indexed as

HydrogelsStem Cell TransplantationAnimalsBiocompatible MaterialsHeart Function TestsMiceMice, Inbred C57BLMyocardial InfarctionPolymersBiocompatible MaterialsHydrogelsPolymerscardiac repairCopolymerhydrogelmesenchymal stem cellsmyocardial infarction

Identifiers

PMID25432986
PMCPMC4935272
OpenAlexW2013698723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.