ArticleBMJ case reports2014
Vanishing bile duct syndrome in the context of concurrent temozolomide for glioblastoma.
Article in BMJ case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel.NPJ breast cancer · 2019Article
- Vanishing bile duct syndrome with hyperlipidemia after ibuprofen therapy in an adult patient: a case report.BMC gastroenterology · 2018Article
- Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements.Hepatology (Baltimore, Md.) · 2017Article
- Temozolomide-induced biliary ductopenia: a case report.Journal of medical case reports · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temozolomide, an oral alkylating agent, is used in the treatment of glioblastoma. We describe a case of a 62-year-old woman developing jaundice with significant derangement of liver function tests on day 17 of focal radiotherapy with concomitant temozolomide. There was no structural abnormality on imaging and liver biopsy was performed. Pathology revealed absence of small terminal bile ducts affecting up to 60% of sampled portal tracts and senescence of many of the remaining small bile ducts, in keeping with a diagnosis of acute vanishing bile duct syndrome. This is a rare syndrome. It has been documented in association with Hodgkin's lymphoma and viral causes. Drugs implicated as precipitating this condition include antiseizure medications, some antibiotics, ibuprofen and antifungals. Temozolomide was stopped. The patient received supportive care, ursodeoxycholic acid 750 mg daily and cholestyramine 4 g twice daily. She was otherwise asymptomatic and her blood results returned to normal by day 129.
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