Evidence map›Paper›PMID 25432901›Full record

ReviewCurrent hypertension reports2015

Familial aggregation and childhood blood pressure.

Xiaoling Wang, Xiaojing Xu, Shaoyong Su, Harold Snieder

Abstract readReview
In one paragraph

Review in Current hypertension reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pre-pregnancy parental BMI and offspring blood pressure in infancy.European journal of preventive cardiology · 2019
    Trial
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Genetics of Hypertension: From Monogenic Analysis to GETomics.Journal of cardiovascular development and disease · 2024
    Review
  8. Article
  9. Hypertension in adolescents: The role of obesity and family history.Journal of clinical hypertension (Greenwich, Conn.) · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xiaoling WangGeorgia Prevention Center, Medical College of Georgia, Georgia Regents University, HS-1640, Augusta, GA, 30912, USA, xwang@gru.edu.
Xiaojing Xu
Shaoyong Su
Harold Snieder
Augusta University · USUniversity of Groningen · NL

Funding

Epigenetic Basis of Obesity Induced Cardiovascular Disease and Type 2 DiabetesR01HL105689 · NHLBI · AUGUSTA UNIVERSITY · PI WANG, XIAOLING · 2011 to 2015
$3.3M
A GENOME-WIDE METHYLATION STUDY ON ESSENTIAL HYPERTENSIONR01HL104125 · NHLBI · AUGUSTA UNIVERSITY · PI WANG, XIAOLING · 2011 to 2015
$2.9M
NHLBI NIH HHS R01 HL104125NHLBI NIH HHS R01HL104125NHLBI NIH HHS R01 HL105689NHLBI NIH HHS R01HL105689
6 · The paper itself

Abstract

There is growing concern about elevated blood pressure (BP) in children. The evidence for familial aggregation of childhood BP is substantial. Twin studies have shown that a large part of the familial aggregation of childhood BP is due to genes. The first part of this review provides the latest progress in gene finding for childhood BP, focusing on the combined effects of multiple loci identified from the genome-wide association studies on adult BP. We further review the evidence on the contribution of the genetic components of other family risk factors to the familial aggregation of childhood BP including obesity, birth weight, sleep quality, sodium intake, parental smoking, and socioeconomic status. At the end, we emphasize the promise of using genomic-relatedness-matrix restricted maximum likelihood (GREML) analysis, a method that uses genome-wide data from unrelated individuals, in answering a number of unsolved questions in the familial aggregation of childhood BP.

Indexed as

FamilyGenetic Predisposition to DiseaseHypertensionBlood PressureChildGenome-Wide Association StudyGlobal HealthHumansMorbidityRisk Factors

Identifiers

PMID25432901
PMCPMC4476022
OpenAlexW2012051446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.