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ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2015

Integrating health-related quality of life findings from randomized clinical trials into practice: an international study of oncologists' perspectives.

Julie Rouette, Jane Blazeby, Madeleine King, Melanie Calvert, Yingwei Peng, Ralph M Meyer, Jolie Ringash, Melanie Walker, Michael D Brundage

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Review
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  8. Article
  9. Review
  10. Article
  11. Importance of Assessing Patient-Reported Outcomes With Salvage Autologous Transplantation in Relapsed Multiple Myeloma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Article
  12. Article
  13. Standards of reporting: the use of CONSORT PRO and CERT in individuals living with osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Review
  14. Presenting comparative study PRO results to clinicians and researchers: beyond the eye of the beholder.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018
    Article
  15. Preliminary evidence on the uptake, use and benefits of the CONSORT-PRO extension.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julie RouetteDivision of Cancer Care and Epidemiology, Level 2, Queen's Cancer Research Institute, 10 Stuart St., Kingston, ON, K7L 3N6, Canada, julie.rouette@queensu.ca.
Jane Blazeby
Madeleine King
Melanie Calvert
Yingwei Peng
Ralph M Meyer
Jolie Ringash
Melanie Walker
Michael D Brundage

Funding

CIHR 394921Medical Research Council MR/K025643/1
6 · The paper itself

Abstract

purposeAlthough health-related quality of life (HRQL) is increasingly assessed in randomized controlled trials (RCTs), HRQL findings are not always incorporated into clinical decision making. We examined the current perspectives of oncologists on the use of HRQL findings from RCTs, and variation of these perspectives between countries and specialties.

methodsA cross-sectional e-survey of oncologist members of the NCIC Clinical Trials Group, the United Kingdom National Cancer Research Institute Clinical Studies Groups, and the Australia/New Zealand cancer clinical trials network was conducted. Respondents reported their perceptions of the usefulness of RCT HRQL outcomes for informing practice, their use of HRQL findings in practice, barriers/facilitators to this use, and preferences for HRQL data presentation in RCT publications. Chi-square tests compared responses between countries and specialties.

resultsA total of 396 oncologists participated (estimated response rate: 30%). The most frequently reported specialties were medical (46%) and radiation (37%) oncology. HRQL findings from RCTs were reported as useful (73%), but were infrequently used to guide clinical decisions with patients. Perceived barriers were lack of time (67%) and understanding (57%), and concerns about generalizability of results (68%). Identified facilitators included joint publication of HRQL/clinical outcomes (96%) and summary of clinical implications of HRQL findings in RCT publications (76%). Use of HRQL findings, perceived barriers/facilitators, and presentation preferences did not differ by country or specialty.

conclusionsOncologists support HRQL findings from RCTs, but perceive important barriers to their use in clinical decision making, regardless of country or specialty. Combined, clear reporting of HRQL/clinical data may facilitate their clinical application.

Indexed as

Clinical Decision-MakingHealth Knowledge, Attitudes, PracticeQuality of LifeAustraliaBiomedical ResearchCross-Sectional StudiesFemaleHumansMaleNeoplasmsNew ZealandPhysiciansRandomized Controlled Trials as TopicSurveys and QuestionnairesTimeUnited Kingdom

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.