ArticleEuropean radiology2015
Contrast agent and radiation dose reduction in abdominal CT by a combination of low tube voltage and advanced image reconstruction algorithms.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 67 citations in OpenAlex.
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- Evaluation of image quality between hybrid iterative reconstruction and deep learning reconstruction in low dose abdominopelvic CT in low body mass index individuals.Scientific reports · 2026Article
- Spectral Computed Tomography Angiography in Visceral Artery Aneurysms: Technical Principles and Clinical Applications.Tomography (Ann Arbor, Mich.) · 2026Review
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- A comparison of the image quality between deep learning reconstruction algorithm and iDose4 using low dose abdominopelvic computed tomography for individuals with normal BMI.SAGE open medicine · 2025Article
- A nomogram model for predicting lymph node metastasis of rectal cancer by combining preoperative magnetic resonance imaging signs and tumour markers.Polish journal of radiology · 2025Article
- Optimizing Arterial Vessel Contrast in Portal Venous Phase with Virtual Monoenergetic Images from Photon-Counting Detector CT Scans of the Abdomen-First Clinical Experiences.Diagnostics (Basel, Switzerland) · 2024Article
- Impact of CT Photon-Counting Virtual Monoenergetic Imaging on Visualization of Abdominal Arterial Vessels.Diagnostics (Basel, Switzerland) · 2023Article
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- A patient- and acquisition-tailored injection approach for improving consistency of CT enhancement towards a target CT value in coronary CT angiography.Journal of applied clinical medical physics · 2023Article
- A dose-neutral image quality comparison of different CBCT and CT systems using paranasal sinus imaging protocols and phantoms.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Effect of Body Mass Index in Coronary CT Angiography Performed on a 256-Slice Multi-Detector CT Scanner.Diagnostics (Basel, Switzerland) · 2022Article
- Finding the optimal tube current and iterative reconstruction strength in liver imaging; two needles in one haystack.PloS one · 2022Article
- Potential increase in radiation-induced DNA double-strand breaks with higher doses of iodine contrast during coronary CT angiography.Medical physics · 2021Article
- Impact of iodine concentration and scan parameters on image quality, contrast enhancement and radiation dose in thoracic CT.European radiology experimental · 2020Article
- Potential value of CT radiomics in the distinction of intestinal-type gastric adenocarcinomas.European radiology · 2020Article
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- Optimization of HU threshold for coronary artery calcium scans reconstructed at 0.5-mm slice thickness using iterative reconstruction.Journal of applied clinical medical physics · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess image quality in abdominal CT at low tube voltage combined with two types of iterative reconstruction (IR) at four reduced contrast agent dose levels.
methodsMinipigs were scanned with standard 320 mg I/mL contrast concentration at 120 kVp, and with reduced formulations of 120, 170, 220 and 270 mg I/mL at 80 kVp with IR. Image quality was assessed by CT value, dose normalized contrast and signal to noise ratio (CNRD and SNRD) in the arterial and venous phases. Qualitative analysis was included by expert reading.
resultsProtocols with 170 mg I/mL or higher showed equal or superior CT values: aorta (278-468 HU versus 314 HU); portal vein (205-273 HU versus 208 HU); liver parenchyma (122-146 HU versus 115 HU). In the aorta, all 170 mg I/mL protocols or higher yielded equal or superior CNRD (15.0-28.0 versus 13.7). In liver parenchyma, all study protocols resulted in higher SNRDs. Radiation dose could be reduced from standard CTDIvol = 7.8 mGy (6.2 mSv) to 7.6 mGy (5.2 mSv) with 170 mg I/mL.
conclusionCombining 80 kVp with IR allows at least a 47 % contrast agent dose reduction and 16 % radiation dose reduction for images of comparable quality. KEY POINTS: • There is a balance between image quality, contrast dose and radiation dose. • Iterative reconstruction has a major, positive impact on this balance. • Both contrast dose and radiation dose can be reduced in abdominal CT. • The trade-off can be quantitatively described by a 3D model. • Contrast and radiation dose can be tailored according to specific safety concerns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.