ArticleeLife2014
CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
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- Non-Canonical Roles of Apoptotic Caspases in the Nervous System.Frontiers in cell and developmental biology · 2022Review
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- BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription.Development (Cambridge, England) · 2021Article
- Germ cell apoptosis is critical to maintain Caenorhabditis elegans offspring viability in stressful environments.PloS one · 2021Article
- Non-apoptotic roles of apoptotic proteases: new tricks for an old dog.Open biology · 2020Review
- Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development.Developmental cell · 2020Article
- Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death.Scientific reports · 2020Article
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- The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28.Developmental cell · 2019Article
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- Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different.Open biology · 2018Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic redundancy and pleiotropism have limited the discovery of functions associated with miRNAs and other regulatory mechanisms. To overcome this, we performed an enhancer screen for developmental defects caused by compromising both global miRISC function and individual genes in Caenorhabditis elegans. Among 126 interactors with miRNAs, we surprisingly found the CED-3 caspase that has only been well studied for its role in promoting apoptosis, mostly through protein activation. We provide evidence for a non-apoptotic function of CED-3 caspase that regulates multiple developmental events through proteolytic inactivation. Specifically, LIN-14, LIN-28, and DISL-2 proteins are known miRNA targets, key regulators of developmental timing, and/or stem cell pluripotency factors involved in miRNA processing. We show CED-3 cleaves these proteins in vitro. We also show CED-3 down-regulates LIN-28 in vivo, possibly rendering it more susceptible to proteasomal degradation. This mechanism may critically contribute to the robustness of gene expression dynamics governing proper developmental control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.