ArticleThe Permanente journal2015
Nasal methicillin-resistant Staphylococcus aureus polymerase chain reaction: a potential use in guiding antibiotic therapy for pneumonia.
Article in The Permanente journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Evaluation of a Pharmacist-Led Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Implementation of MRSA Nasal Swabs as an Antimicrobial Stewardship Intervention to Decrease Anti-MRSA Therapy in COVID-19 Infection.Antibiotics (Basel, Switzerland) · 2023Article
- Use of nares swab to de-escalate vancomycin for patients with suspected methicillin-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Evaluating the Role ofThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Pharmacist-Driven MRSA Nasal PCR Screening and the Duration of Empirical Vancomycin Therapy for Suspected MRSA Respiratory Tract Infections.Mayo Clinic proceedings. Innovations, quality & outcomes · 2020Article
- Evaluation of a pharmacy-driven methicillin-resistant Staphylococcus aureus surveillance protocol in pneumonia.International journal of clinical pharmacy · 2018Article
- Management of methicillin-resistantCurrent trends in microbiology · 2018Article
- Nasal Methicillin-Resistant Staphylococcus aureus (MRSA) PCR Testing Reduces the Duration of MRSA-Targeted Therapy in Patients with Suspected MRSA Pneumonia.Antimicrobial agents and chemotherapy · 2017Article
- PCR-based Approaches for the Detection of Clinical Methicillin-resistant Staphylococcus aureus.The open microbiology journal · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe role at admission of nasal polymerase chain reaction (PCR) for patients with methicillin-resistant Staphylococcus aureus (MRSA) in guiding antibiotic therapy for lower respiratory tract infection is unknown.
objectiveTo determine whether nasal MRSA PCR at admission can predict the absence of MRSA in lower respiratory tract secretions.
designWe performed a retrospective study of adult patients admitted to a large urban hospital. Patients had a nasal MRSA PCR test and a lower respiratory tract culture obtained within 48 hours of admission and the culture yielded S aureus.
main outcome measuresSensitivity, specificity, and positive and negative predictive values.
resultsOur results showed high sensitivity (93.3%) and negative predictive value (95.2%) of nasal PCR for MRSA in the lower respiratory tract.
conclusionWith its high sensitivity and negative predictive value, a nasal MRSA PCR test performed within 48 hours of hospital admission could help guide the discontinuation of MRSA-directed empiric antibiotic therapy in patients who are unlikely to be infected with this organism. A prospective study is needed to confirm these findings.
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