ArticleThe Biochemical journal2015
A directed-overflow and damage-control N-glycosidase in riboflavin biosynthesis.
Article in The Biochemical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Anaerobic riboflavin degradation by human gutJournal of bacteriology · 2026Article
- Anaerobic riboflavin degradation by human gutbioRxiv : the preprint server for biology · 2026Article
- ADP-Ribosylation of Cytidine: A Novel Nucleic Acid Modification Reversed by NADAR Hydrolases.Toxins · 2026Article
- Recent advances in metabolic engineering of Escherichia coli for riboflavin biosynthesis.World journal of microbiology & biotechnology · 2025Review
- Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system.Nature communications · 2025Article
- Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system.bioRxiv : the preprint server for biology · 2024Article
- Genome streamlining in Parcubacteria transitioning from soil to groundwater.Environmental microbiome · 2024Article
- Article
- Molecular basis for the reversible ADP-ribosylation of guanosine bases.Molecular cell · 2023Article
- Apprehending the NADViruses · 2022Article
- A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex.Nucleic acids research · 2022Article
- Characterization of Stenotrophomonas maltophilia phage AXL1 as a member of the genus Pamexvirus encoding resistance to trimethoprim-sulfamethoxazole.Scientific reports · 2022Article
- Application of Counter-wound Multi-arm Spirals in HTS Resonator Design.IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee · 2022Article
- Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity inJournal of physics. Conference series · 2022Article
- Progress Towards a Higher SensitivityIEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee · 2021Article
- Nitric oxide as a source for bacterial triazole biosynthesis.Nature communications · 2020Article
- Maize Dek33 encodes a pyrimidine reductase in riboflavin biosynthesis that is essential for oil-body formation and ABA biosynthesis during seed development.Journal of experimental botany · 2019Article
- Optimization of an Ultrasound-Assisted Extraction for Simultaneous Determination of Antioxidants in Sesame with Response Surface Methodology.Antioxidants (Basel, Switzerland) · 2019Article
- Novel Stenotrophomonas maltophilia temperate phage DLP4 is capable of lysogenic conversion.BMC genomics · 2019Article
- Transcriptomics reveals a cross-modulatory effect between riboflavin and iron and outlines responses to riboflavin biosynthesis and uptake in Vibrio cholerae.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
Plants and bacteria synthesize the essential human micronutrient riboflavin (vitamin B2) via the same multi-step pathway. The early intermediates of this pathway are notoriously reactive and may be overproduced in vivo because riboflavin biosynthesis enzymes lack feedback controls. In the present paper, we demonstrate disposal of riboflavin intermediates by COG3236 (DUF1768), a protein of previously unknown function that is fused to two different riboflavin pathway enzymes in plants and bacteria (RIBR and RibA respectively). We present cheminformatic, biochemical, genetic and genomic evidence to show that: (i) plant and bacterial COG3236 proteins cleave the N-glycosidic bond of the first two intermediates of riboflavin biosynthesis, yielding relatively innocuous products; (ii) certain COG3236 proteins are in a multi-enzyme riboflavin biosynthesis complex that gives them privileged access to riboflavin intermediates; and (iii) COG3236 action in Arabidopsis thaliana and Escherichia coli helps maintain flavin levels. COG3236 proteins thus illustrate two emerging principles in chemical biology: directed overflow metabolism, in which excess flux is diverted out of a pathway, and the pre-emption of damage from reactive metabolites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.