Evidence map›Paper›PMID 25431627›Full record

ArticleNeurology Asia2013

A review of neuroimaging biomarkers of Alzheimer's disease.

Tinu Varghese, R Sheelakumari, Jija S James, Ps Mathuranath

Abstract read
In one paragraph

Article in Neurology Asia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Insight into the Molecular Imaging of Alzheimer's Disease.International journal of biomedical imaging · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tinu VargheseCognition and Behavioral Neurology Section, Department of Neurology, Trivandrum ; Department of Electronics and Instrumentation, Noorul Islam University, Kumaracoil, Thuckalay, Tamilnadu.
R SheelakumariCognition and Behavioral Neurology Section, Department of Neurology, Trivandrum.
Jija S JamesDepartment of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum.
Ps MathuranathCognition and Behavioral Neurology Section, Department of Neurology, Trivandrum ; Cognition & Behavioural Neurology Section, Department of Neurology, National Institute of Mental Health & Neuro Sciences, Banglore, India.

Funding

Kerala-Einstein Study: Healthy lifestyle, vascular disease, and cognitive declineR01AG039330 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MATHURANATH, PAVAGADA S, VERGHESE, JOE · 2011 to 2023
$5.0M
Kerala-Einstein study: Risk factors for cognitive declineR21AG029799 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI VERGHESE, JOE · 2008 to 2009
$245k
NIA NIH HHS R01 AG039330NIA NIH HHS R21 AG029799
6 · The paper itself

Abstract

Neuroimaging biomarkers have potential role in the early diagnosis as well as periodic follow-up of neurodegenerative diseases such as Alzheimer's disease (AD). Structural imaging biomarkers can be used to predict those who are at risk or in preclinical stages of AD. It could possibly be useful even in predicting the conversion of Mild Cognitive Impairment (MCI) an early stage of AD to AD. In addition there has been a lot of progress in molecular imaging in AD. This article presents a review of recent progress in selected imaging biomarkers for early diagnosis, classification, and progression, of AD. A comprehensive integrative strategy initiated early in the cognitive decline is perhaps the most effective method of controlling progression to Alzheimer's disease.

Identifiers

PMID25431627
PMCPMC4243931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.