Evidence map›Paper›PMID 25431545›Full record

ArticleAmerican journal of lifestyle medicine2007

The Anti-Inflammatory Actions of Exercise Training.

Michael G Flynn, Brian K McFarlin, Melissa M Markofski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of lifestyle medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 149 citations in OpenAlex.

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  8. Effect ofNutrients · 2019
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  9. Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Michael G FlynnWastl Human Performance Lab, Department of Health and Kinesiology, Purdue University West Lafayette, Indiana (MGF, MMM) and the Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, Texas (BKM).
Brian K McFarlinWastl Human Performance Lab, Department of Health and Kinesiology, Purdue University West Lafayette, Indiana (MGF, MMM) and the Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, Texas (BKM).
Melissa M MarkofskiWastl Human Performance Lab, Department of Health and Kinesiology, Purdue University West Lafayette, Indiana (MGF, MMM) and the Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, Texas (BKM).
Purdue University West Lafayette · USUniversity of Houston · US

Funding

Monocyte / Macrophage TLR4 Expression and Signaling: A Link between Obesity and CR03AG028110 · NIA · UNIVERSITY OF HOUSTON · PI MCFARLIN, BRIAN KEITH · 2007 to 2008
$121k
NIA NIH HHS R03 AG028110
6 · The paper itself

Abstract

The list of diseases with a known inflammatory etiology is growing. Cardiovascular disease, osteoporosis, diabetes, geriatric cachexia, and Alzheimer's disease have all been shown to be linked to or exacerbated by aberrantly regulated inflammatory processes. Nevertheless, there is mounting evidence that those who are physically active, or who become physically active, have a reduction in biomarkers associated with chronic inflammation. There was strong early consensus that exercise-induced reductions in inflammation were explained by body mass index or body fatness, but recent studies provide support for the contention that exercise has body fat-independent anti-inflammatory effects. With few exceptions, the anti-inflammatory effects of exercise appear to occur regardless of age or the presence of chronic diseases. What remains unclear are the mechanisms by which exercise training induces these anti-inflammatory effects, but there are several intriguing possibilities, including release of endogenous products, such as heat shock proteins; selective reduction of visceral adipose tissue mass or reducing infiltration of adipocytes by macrophages; shift in immune cell phenotype; cross-tolerizing effects; or exercise-induced shifts in accessory proteins of toll-like receptor signaling. However, future research endeavors are likely to uncover additional potential mechanisms, and it could be some time before functional mechanisms are made clear. In summary, the potential anti-inflammatory influences of exercise training may provide a low-cost, readily available, and effective treatment for low-grade systemic inflammation and could contribute significantly to the positive effects of exercise training on chronic disease.

Indexed as

anti-inflammatorychronic diseaseexercise training

Identifiers

PMID25431545
PMCPMC4243532
OpenAlexW2017675047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.