ArticleScience (New York, N.Y.)2015
Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics.
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Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 328 papers.
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328citing papers in PubMed
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328 citing papers in PubMed, 721 citations in OpenAlex.
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- Article
- Introgression across Narrow Contact Zones Shapes the Genomic Landscape of Phylogenetic Variation in an African Bird Clade.Systematic biology · 2025Article
- Behavioral divergence between a generalist and a specialist mosquito despite minimal differentiation across chemosensory receptor gene families.bioRxiv : the preprint server for biology · 2025Article
268 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 9 institutions in 4 countries.
Michael C FontaineDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
James B PeaseDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Aaron SteeleDepartment of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Robert M WaterhouseComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.
Daniel E NeafseyThe Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Igor V SharakhovDepartment of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. The Interdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Xiaofang JiangThe Interdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Andrew B HallThe Interdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Flaminia CatterucciaDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
Evdoxia KakaniDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
Sara N MitchellDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Yi-Chieh WuComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.
Hilary A SmithDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
R Rebecca LoveDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
Mara K LawniczakDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Michel A SlotmanDepartment of Entomology, Texas A&M University, College Station, TX 77843, USA.
Scott J EmrichEck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA. Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Matthew W HahnDepartment of Biology, Indiana University, Bloomington, IN 47405, USA. School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA. mwh@indiana.edu nbesansk@nd.edu.
Nora J BesanskyDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA. mwh@indiana.edu nbesansk@nd.edu.
University of Notre Dame · USVirginia Tech · USHarvard University · USIndiana University Bloomington · USVassar College · USBroad Institute · USImperial College London · GBTexas A&M University · USUniversity of Perugia · IT
Funding
TRAINING IN GENETICST32GM007757 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI KUMAR, JUSTIN P · 1985 to 2014
$8.1MTargeting the reproductive interactome of the malaria vector Anopheles gambiaeR01AI104956 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CATTERUCCIA, FLAMINIA · 2013 to 2017
$3.0MEcological Genomics of Anopheles gambiaeR01AI063508 · NIAID · UNIVERSITY OF NOTRE DAME · PI BESANSKY, NORA JESSIE · 2005 to 2009
$2.7MFunctional Genomics of Inversion 2La in Anopheles gambiaeR01AI076584 · NIAID · UNIVERSITY OF NOTRE DAME · PI BESANSKY, NORA JESSIE · 2009 to 2013
$2.4MThe Genetic Basis of Anthropophily in Anopheles gambiaeR01AI085079 · NIAID · TEXAS A&M AGRILIFE RESEARCH · PI SLOTMAN, MICHEL A · 2010 to 2013
$1.0MHighly finished chromosome-based genome assembly for Anopheles gambiaeR21AI094289 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SHARAKHOV, IGOR V · 2011 to 2012
$420kComparative genome mapping of the Anopheles species clusterR21AI099528 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SHARAKHOV, IGOR V · 2014 to 2015
$419kGenetic basis of salt tolerance in Anopheles gambiae s.l.R21AI101459 · NIAID · UNIVERSITY OF NOTRE DAME · PI BESANSKY, NORA JESSIE · 2012 to 2013
$401kMedical Research Council G1100339NIAID NIH HHS HHSN272200900039CNIAID NIH HHS R01 AI063508NIAID NIH HHS R01 AI076584NIAID NIH HHS R01AI076584NIAID NIH HHS R01 AI085079NIAID NIH HHS R01AI085079NIAID NIH HHS R01 AI104956NIAID NIH HHS R01AI104956NIAID NIH HHS R21 AI094289NIAID NIH HHS R21AI094289NIAID NIH HHS R21 AI099528NIAID NIH HHS R21AI099528NIAID NIH HHS R21 AI101459NIAID NIH HHS R21AI101459NIGMS NIH HHS T32 GM007757NIGMS NIH HHS T32GM007757
Abstract
Introgressive hybridization is now recognized as a widespread phenomenon, but its role in evolution remains contested. Here, we use newly available reference genome assemblies to investigate phylogenetic relationships and introgression in a medically important group of Afrotropical mosquito sibling species. We have identified the correct species branching order to resolve a contentious phylogeny and show that lineages leading to the principal vectors of human malaria were among the first to split. Pervasive autosomal introgression between these malaria vectors means that only a small fraction of the genome, mainly on the X chromosome, has not crossed species boundaries. Our results suggest that traits enhancing vectorial capacity may be gained through interspecific gene flow, including between nonsister species.
Indexed as
Evolution, MolecularGenome, InsectAnimalsAnophelesChromosomes, InsectGenomicsHumansInsect VectorsMalariaPhylogenyPolymorphism, GeneticPupaX Chromosome
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