ArticleJournal of biosciences2014
Evolution and expression analysis of the soybean glutamate decarboxylase gene family.
Article in Journal of biosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Evolutionary dynamics and transcriptional diversification of GAD gene family in plants: a pan-species perspective in silico analysis.BMC plant biology · 2025Article
- Genome-wide identification and analysis of theFrontiers in plant science · 2022Article
- Exogenous Spermidine Promotes γ-Aminobutyric Acid Accumulation and Alleviates the Negative Effect of NaCl Stress in Germinating Soybean (Foods (Basel, Switzerland) · 2020Article
- Direct neurotransmitter activation of voltage-gated potassium channels.Nature communications · 2018Article
- Molecular Evolution and Functional Diversification of Replication Protein A1 in Plants.Frontiers in plant science · 2016Article
- Evolutionary Trails of Plant Group II Pyridoxal Phosphate-Dependent Decarboxylase Genes.Frontiers in plant science · 2016Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate decarboxylase (GAD) is an enzyme that catalyses the conversion of L-glutamate into gamma-aminobutyric acid (GABA), which is a four-carbon non-protein amino acid present in all organisms. Although plant GAD plays important roles in GABA biosynthesis, our knowledge concerning GAD gene family members and their evolutionary relationship remains limited. Therefore, in this study, we have analysed the evolutionary mechanisms of soybean GAD genes and suggested that these genes expanded in the soybean genome partly due to segmental duplication events. The approximate dates of duplication events were calculated using the synonymous substitution rate, and we suggested that the segmental duplication of GAD genes in soybean originated 9.47 to 11.84 million years ago (Mya). In addition, all segmental duplication pairs (GmGAD1/3 and GmGAD2/4) are subject to purifying selection. Furthermore, GmGAD genes displayed differential expression either in their transcript abundance or in their expression patterns under abiotic stress conditions like salt, drought, and cold. The expression pattern of paralogous pairs suggested that they might have undergone neofunctionalization during the subsequent evolution process. Taken together, our results provide valuable information for the evolution of the GAD gene family and represent the basis for future research on the functional characterization of GAD genes in higher plants.
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