ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2015
Nuclear expression and gain-of-function β-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 85 citations in OpenAlex.
- Diagnostic Insights and Surgical Outcomes of Glomangiopericytoma: A Tertiary Center Case Series.Journal of rhinology : official journal of the Korean Rhinologic Society · 2026Article
- Proceedings of the 2026 North American Society of Head and Neck Pathology Companion Meeting, San Antonio, TX, March 22, 2026: It's a Trap!: Diagnostic Pitfalls in Sinonasal Pathology.Head and neck pathology · 2026Review
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- Intranodal palisaded myofibroblastoma shows a unique epigenetic profile-first molecular study of their epigenetic and copy number variation profile.Virchows Archiv : an international journal of pathology · 2025Article
- S100-positive stroma in salivary gland basal cell adenomas: a neoplastic component with CTNNB1 mutations.Virchows Archiv : an international journal of pathology · 2025Article
- Utility of LEF1 to differentiate desmoid fibromatosis from its histologic mimics.Virchows Archiv : an international journal of pathology · 2024Article
- CTNNB1 mutation-driven hybrid tumor: desmoid fibromatosis with an unusual associated epithelioid component arising in association with a neuromuscular choristoma.Virchows Archiv : an international journal of pathology · 2024Article
- Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors.Current oncology reports · 2024Review
- Glomangiopericytoma withBMJ case reports · 2023Article
- Top 10 Significant Spindled Head and Neck Lesions to Scrutinze.Head and neck pathology · 2023Review
- Clinical and histopathological findings of a rare sinonasal glomangiopericytoma.Autopsy & case reports · 2023Article
- Combined Neuroendocrine and Squamous Cell Carcinoma of the Sinonasal Tract: A Morphologic and Immunohistochemical Analysis and Review of Literature.Head and neck pathology · 2022Review
- Sinonasal Glomangiopericytoma with Prolonged Postsurgical Follow-Up.Journal of neurological surgery reports · 2022Article
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base.Head and neck pathology · 2022Review
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- Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.Journal of cancer research and clinical oncology · 2021Article
- Loss of CTNNB1 exon 3 in sclerosing angiomatoid nodular transformation of the spleen.Virchows Archiv : an international journal of pathology · 2021Article
- Biphenotypic sinonasal sarcoma: Report of 3 cases with a review of literature.Human pathology (New York) · 2021Article
- Orbit Solitary Fibrous Tumor: A Proposed Risk Prediction Model Based on a Case Series and Comprehensive Literature Review.Head and neck pathology · 2021Review
- MVP predicts the pathogenicity of missense variants by deep learning.Nature communications · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Glomangiopericytoma (sinonasal-type hemangiopericytoma) is a rare mesenchymal neoplasm with myoid phenotype (smooth muscle actin-positive), which distinguishes this tumor from soft tissue hemangiopericytoma/solitary fibrous tumor. Molecular genetic changes underlying the pathogenesis of glomangiopericytoma are not known. In this study, 13 well-characterized glomangiopericytomas were immunohistochemically evaluated for β-catenin expression. All analyzed tumors showed strong expression and nuclear accumulation of β-catenin. Following this observation, β-catenin glycogen serine kinase-3 beta phosphorylation region, encoded by exon 3, was PCR amplified in all cases and evaluated for mutations using Sanger sequencing. Heterozygous mutations were identified in 12 of 13 tumors. All mutations consisted of single-nucleotide substitutions: three in codon 32 (c.94G>C (n=2) and c.95A>T), four in codon 33 (two each c.98C>G and c.98C>T), two in codon 37 (c.109T>G), one in codon 41 (c.121A>G), and two in codon 45 (c.133T>C). At the protein level, these substitutions would lead to p.D32H, p.D32V, p.S33C, p.S33F, p.S37A, p.T41A, and p.S45L mutations, respectively. Previously, similar mutations have been reported in different types of cancers and shown to trigger activation of β-catenin signaling. All analyzed glomangiopericytomas showed prominent nuclear expression of cyclin D1, as previously shown for tumors with nuclear expression of β-catenin as a sign of oncogenic activation. These results demonstrate that mutational activation of β-catenin and associated cyclin D1 overexpression may be central events in the pathogenesis of glomangiopericytoma. In additon, nuclear accumulation of β-catenin is a diagnostic marker for glomangiopericytoma.
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