Evidence map›Paper›PMID 25431071›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2015

Stem cells, neural progenitors, and engineered stem cells.

Raj R Rao, Shilpa Iyer

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Raj R RaoDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 West Main Street, Room 410, Richmond, VA, 23284-3028, USA.
Shilpa Iyer

Funding

mtDNA heteroplasmy in development and differentiation: an in-vitro approachR15NS080157 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI IYER, SHILPA · 2013 to 2013
$352k
NINDS NIH HHS R15 NS080157
6 · The paper itself

Abstract

Human pluripotent stem cells (hPSCs ) have the unique potential to form every cell type in the body. This potential provides opportunities for generating human progenitors and other differentiated cell types for understanding human development and for use in cell type-specific therapies. Equally important is the ability to engineer stem cells and their derived progenitors to mimic specific disease models. This chapter will focus on the propagation and characterization of human neural progenitors (hNPs ) derived from hPSCs with a particular focus on engineering hNPs to generate in vitro disease models for human neuro-mitochondrial disorders. We will discuss the methodologies for culturing and characterizing hPSCs and hNPs; and protocols for engineering hNPs by using a novel mitochondrial transfection technology.

Indexed as

Pluripotent Stem CellsCell Culture TechniquesCell DifferentiationCell EngineeringHumansMolecular BiologyNeural Stem Cells

Identifiers

PMID25431071
PMCPMC5642280

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.