Evidence map›Paper›PMID 25430965›Full record

ArticleCell research2015

One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system.

Haifeng Wan, Chunjing Feng, Fei Teng, Shihua Yang, Baoyang Hu, Yuyu Niu, Andy Peng Xiang, Weizhen Fang, Weizhi Ji, Wei Li and 2 more

Abstract readLetter
In one paragraph

Article in Cell research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Article
  2. Liver-specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. AeLife · 2024
    Article
  4. Article
  5. Ablation ofPNAS nexus · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Gene editing monkeys: Retrospect and outlook.Frontiers in cell and developmental biology · 2022
    Review
  13. Article
  14. Application of CRISPR/Cas9 System in Establishing Large Animal Models.Frontiers in cell and developmental biology · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. The dawn of non-human primate models for neurodevelopmental disorders.Current opinion in genetics & development · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haifeng WanState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Chunjing Feng1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Fei Teng1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Shihua Yang1] College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China [2] Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province, Guangzhou, Guangdong 510642, China.
Baoyang HuState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Yuyu NiuYunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China.
Andy Peng XiangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Weizhen FangBeijing Xieerxin Institute of Biological Resources, Beijing, China.
Weizhi JiYunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China.
Wei LiState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Xiaoyang ZhaoState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Qi ZhouState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnimals, Genetically ModifiedBase SequenceClustered Regularly Interspaced Short Palindromic RepeatsEmbryo, MammalianMacaca fascicularisMutagenesisRNATumor Suppressor Protein p53RNATumor Suppressor Protein p53

Identifiers

PMID25430965
PMCPMC4650568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.