ArticleBMC veterinary research2014
Increased concentrations of Serum amyloid A in dogs with sepsis caused by pyometra.
Article in BMC veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Septic Shock and Prognosis in Dogs and Cats With Sepsis-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Retinal vascular calibers and correlations with biomarkers in bitches with pyometra-induced systemic inflammatory response syndrome.Veterinary world · 2025Article
- Molecular Factors Involved in the Pathogenesis of Pyometra in Domestic Cats (Animals : an open access journal from MDPI · 2024Review
- Postoperative complications and antibiotic use in dogs with pyometra: a retrospective review of 140 cases (2019).Acta veterinaria Scandinavica · 2023Article
- Apolipoprotein A1 and serum amyloid A in dogs with sepsis and septic shock.Frontiers in veterinary science · 2023Article
- Evaluation of Resting Serum Bile Acid Concentrations in Dogs with Sepsis.Veterinary sciences · 2022Article
- Serum Amyloid A as a Promising Biomarker in Domestic Animals' Reproduction: Current Knowledge and Future Perspective.Animals : an open access journal from MDPI · 2022Review
- Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Changes in the Serum Protein Electrophoresis Profile in Dogs With Pyometra.Frontiers in veterinary science · 2021Article
- Closed cervix is associated with more severe illness in dogs with pyometra.BMC veterinary research · 2017Article
- Blood pressure and heart rate during ovariohysterectomy in pyometra and control dogs: a preliminary investigation.Acta veterinaria Scandinavica · 2016Article
- Serum IL-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy.Acta veterinaria Scandinavica · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a serious and potentially life-threatening condition and early diagnosis and appropriate treatment is crucial for survival. Pyometra is one of the most common diseases in intact female dogs. The disease often leads to sepsis (systemic inflammatory response syndrome, SIRS, caused by infection). Diagnostic markers for detecting sepsis are gaining increasing interest in veterinary medicine. Acute phase proteins (APPs) such as C-reactive protein (CRP) are useful for detecting systemic inflammation in dogs. Serum amyloid A (SAA) is another major APP in dogs that is not yet as widely used. Albumin is regarded as a negative APP and has earlier been evaluated for prediction of prognosis in septic dogs. The aim of the present study was to determine SAA, CRP and albumin concentrations in dogs with sepsis and pyometra and to evaluate whether these inflammatory markers are associated with length of postoperative hospitalization.
resultsThirty-one surgically treated bitches with pyometra were included, whereof 23 septic (SIRS-positive) and eight non-septic (SIRS-negative). Albumin concentrations were analyzed by routine automated methods. SAA and CRP analyses were performed with previously validated commercially available assays (ELISA and immunoturbidimetric).Mean (± SE) serum concentrations of SAA were significantly higher in septic (130.8 ± 8.0 mg/L) compared to non-septic bitches (88.5 ± 12.5 mg/L). Using a cut-off value for SAA of 109.07 mg/L (n = 31 bitches), the sensitivity and specificity for detecting sepsis was 74% and 50%, respectively. Serum albumin concentrations were not significantly different in septic compared to non-septic bitches (mean ± SE, 25 ± 1 g/L and 26 ± 1 g/L, respectively). CRP concentrations were also not significantly different in septic (mean ± SE 225.6 ± 16.0 mg/L) compared to non-septic bitches (mean ± SE, 176.0 ± 27.1 mg/L). None of these inflammatory markers were associated with the outcome as measured by length of hospitalization.
conclusionsSAA concentrations were increased in dogs with sepsis induced by pyometra and may be useful as an adjunctive diagnostic marker for sepsis. To evaluate the full potential of SAA as a marker for sepsis also in other diseases, further studies are warranted.
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