ReviewAJNR. American journal of neuroradiology2015
Mechanisms of Healing in Coiled Intracranial Aneurysms: A Review of the Literature.
Review in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 5 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Impact of Smoking on Recurrence and Angiographic Outcomes after Endovascular Treatment of Intracranial Aneurysms: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2025Pooled it
- Hydrogel Coils versus Bare Platinum Coils for the Treatment of Ruptured and Unruptured Aneurysms: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.AJNR. American journal of neuroradiology · 2025Pooled it
- Clinical Outcome of Pipeline Embolization Device with and without Coils to Treat Intracranial Aneurysm: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2025Pooled it
- Endothelialization following Flow Diversion for Intracranial Aneurysms: A Systematic Review.AJNR. American journal of neuroradiology · 2019Pooled it
- Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials.BMC neurology · 2018Pooled it
- The Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): A Randomized Controlled Trial of the Second-Generation Hydrogel Coil.Neurosurgery · 2020Trial
- First-in-human use of SmartGUIDENeuroradiology · 2026Article
- Dome-remnant dissociation after coil embolization of a basilar tip aneurysm: serial MR cisternography, silent MRA, and computational fluid dynamics findings suggest early hemodynamic redistribution. Illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Delayed mass effect following endovascular coiling of posterior inferior cerebellar artery aneurysms: Mechanism and treatment strategy: A case report.Radiology case reports · 2026Article
- Cellular Mechanisms Underlying Endothelial and Histopathological Alterations Induced by Cerebral Angiography.Journal of clinical medicine · 2026Review
- Magnetically-guided, stimuli-responsive microdevices for endovascular therapy.Biomedical microdevices · 2026Article
- CXCL1: a novel therapeutic target to increase aneurysm healing after coil embolization.Frontiers in stroke · 2026Article
- Flow Diverter Stents for Recurrent Intracranial Aneurysms after Stent-Assisted Coil Embolization: Safety, Efficacy, and Technical Considerations-A Comprehensive Review.Journal of neuroendovascular therapy · 2026Review
- Persistent flow inside the Woven EndoBridge at angiographic follow-up: A multicenter study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Chronological Changes in Intra-aneurysmal Signal Intensity on T1-weighted Black Blood Images after Endovascular Treatment for Unruptured Intracranial Aneurysms.Neurologia medico-chirurgica · 2025Observational
- Consensus Statement on Middle Meningeal Artery Embolization in Chronic Subdural Hematoma Treatment: A Guideline from the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee.Stroke (Hoboken, N.J.) · 2025Review
- Earlier and greater vascular endothelial cell proliferation on hydrocoils compared to bare platinum coils: an in vitro study.Scientific reports · 2025Article
- Efficacy and safety of a novel flow-disruptor device in a rabbit aneurysm model: a preliminary study.Scientific reports · 2025Article
- A novel histological occlusion classification for coiled aneurysms based on multiphoton microscopy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Visual symptoms after flow-diverter stenting of internal carotid artery aneurysms: A retrospective cohort study.Surgical neurology international · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recanalization of intracranial aneurysms following endovascular coiling remains a frustratingly common occurrence. An understanding of the molecular and histopathologic mechanisms of aneurysm healing following coil embolization is essential to improving aneurysm occlusion rates. Histopathologic studies in coiled human and experimental aneurysms suggest that during the first month postcoiling, thrombus formation and active inflammation occur within the aneurysm dome. Several months following embolization, the aneurysm is excluded from the parent vessel by formation of a neointimal layer, which is often thin and discontinuous, across the aneurysm neck. Numerous coil modifications and systemic therapies have been tested in animals and humans in an attempt to improve the aneurysm-healing process; these modifications have met with variable levels of success. In this review, we summarize the histopathologic and molecular biology of aneurysm healing and discuss how these findings have been applied in an attempt to improve angiographic outcomes in patients with intracranial aneurysms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.