Evidence map›Paper›PMID 25430685›Full record

SynthesisMedical science monitor : international medical journal of experimental and clinical research2014

Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis.

Junfei Zhao, Hongyuan Wang, Weizhen Hu, Yuanhong Jin

Abstract readMeta-Analysis
In one paragraph

Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.Advances in protein chemistry and structural biology · 2019
    Review
  4. Article
  5. Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  6. Relevance between HLA-DP gene rs2281388 polymorphism and hepatocellular carcinoma risk.International journal of clinical and experimental pathology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junfei ZhaoRespiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).
Hongyuan WangRespiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).
Weizhen HuRespiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).
Yuanhong JinRespiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China (mainland).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility. MATERIAL/

methodsA systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.

resultsTen case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01-1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22-1.37, P<0.01).

conclusionsThis meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.

Indexed as

Genetic Predisposition to DiseaseHumansLung NeoplasmsMolecular ChaperonesPolymorphism, Single NucleotideRisk FactorsBAG6 protein, humanMolecular Chaperones

Identifiers

PMID25430685
PMCPMC4259522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.