Evidence map›Paper›PMID 25430675›Full record

ArticleChembiochem : a European journal of chemical biology2014

A bacterial mutant library as a tool to study the attack of a defensin peptide.

Simone Moser, Haritha R Chileveru, Jill Tomaras, Elizabeth M Nolan

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. The role of glycosylated mucins in maintaining intestinal homeostasis and gut health.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Intracellular Targeting Mechanisms by Antimicrobial Peptides.Antimicrobial agents and chemotherapy · 2017
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simone MoserDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).
Haritha R Chileveru
Jill Tomaras
Elizabeth M Nolan

Funding

Antibacterial Peptides and Zinc in Innate Immunity and Mammalian PhysiologyDP2OD007045 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NOLAN, ELIZABETH M · 2010 to 2010
$2.5M
NIH HHS DP2 OD007045NIH HHS DP2OD007045
6 · The paper itself

Abstract

Defensin attack! Here we report the screening of human defensin 5 against the Keio Collection of E. coli strains. The results of this screen further our understanding of how this important hostdefense peptide kills bacteria and how bacteria protect themselves against the attack from the human host.

Indexed as

Host-Pathogen InteractionsMutationalpha-DefensinsAmino Acid SequenceEscherichia coliEscherichia coli InfectionsGene LibraryHumansImmunity, InnateModels, MolecularMolecular Sequence Dataalpha-DefensinsDEFA5 protein, humanhuman defensinsinnate immunityKeio Collectionknockout mutantslipopolysaccharide

Identifiers

PMID25430675
PMCPMC4341900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.