ArticleProteomics2015
Secretome analysis revealed adaptive and non-adaptive responses of the Staphylococcus carnosus femB mutant.
Article in Proteomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Integrated genomic and proteomic analysis of the mouse-adaptedCurrent research in microbial sciences · 2025Article
- "Applied and environmental microbiology · 2021Article
- Staphylococcus aureus Trigger Factor Is Involved in Biofilm Formation and Cooperates with the Chaperone PpiB.Journal of bacteriology · 2021Article
- Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction.PLoS pathogens · 2021Article
- Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence ofMicroorganisms · 2020Article
- Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b.Nature chemical biology · 2020Article
- Secretome Profiling Reveals Virulence-Associated Proteins ofBiomolecules · 2019Article
- The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis.Frontiers in microbiology · 2019Review
- Lantibiotic production is a burden for the producing staphylococci.Scientific reports · 2018Article
- Genetic Adaptation of a Mevalonate Pathway Deficient Mutant inFrontiers in microbiology · 2018Article
- Non-classical Protein Excretion Is Boosted by PSMα-Induced Cell Leakage.Cell reports · 2017Article
- Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus.Infection and immunity · 2016Article
- Excretion of cytoplasmic proteins in Staphylococcus is most likely not due to cell lysis.Current genetics · 2016Review
- Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response.Infection and immunity · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FemABX peptidyl transferases are involved in non-ribosomal pentaglycine interpeptide bridge biosynthesis. Here, we characterized the phenotype of a Staphylococcus carnosus femB deletion mutant, which was affected in growth and showed pleiotropic effects such as enhanced methicillin sensitivity, lysostaphin resistance, cell clustering, and decreased peptidoglycan cross-linking. However, comparative secretome analysis revealed a most striking difference in the massive secretion or release of proteins into the culture supernatant in the femB mutant than the wild type. The secreted proteins can be categorized into typical cytosolic proteins and various murein hydrolases. As the transcription of the murein hydrolase genes was up-regulated in the mutant, they most likely represent an adaption response to the life threatening mutation. Even though the transcription of the cytosolic protein genes was unaltered, their high abundance in the supernatant of the mutant is most likely due to membrane leakage triggered by the weakened murein sacculus and enhanced autolysins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.