Evidence map›Paper›PMID 25430635›Full record

SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2015

Is tranexamic acid clinically effective and safe to prevent blood loss in total knee arthroplasty? A meta-analysis of 34 randomized controlled trials.

Qiang Wu, Hong-An Zhang, Shi-Long Liu, Tao Meng, Xin Zhou, Ping Wang

Registry-linked trialAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03109652 (Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients), which is not on this map. Cited by 35 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 10 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03109652 phase4unknown statusnot on this mapstarted 2017, after this paper: background citation

Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients: A Randomized Controlled Study

TypeinterventionalSponsorSeoul National University HospitalRan2017 to 2019Enrolled144ConditionsKnee OsteoarthritisArmsTranexamic Acid
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 10 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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  19. Optimizing Intraoperative Blood Management for One-Stage Bilateral Total Knee Arthroplasty.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2018
    Review
  20. The best cited articles of the European Journal of Orthopaedic Surgery and Traumatology (EJOST): a bibliometric analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qiang WuDepartment of Orthopaedics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin, 300000, People's Republic of China.
Hong-An Zhang
Shi-Long Liu
Tao Meng
Xin Zhou
Ping Wang
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine · CNTianjin University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranexamic acid (TXA) is well established as a versatile intraarticular and intravenous (IV) antifibrinolytic agent that has been successfully used to control bleeding after total knee arthroplasty (TKA). The present meta-analysis aimed at assessing the effectiveness and safety of TXA in reducing blood loss and transfusion in TKA.

methodsWe searched the PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar databases from 1966 to December 2013. Only randomized controlled trials (RCTs) were included in the present study. Two independent reviewers identified the eligible studies, assessed their methodological quality, and extracted data. The data were using fixed-effects or random-effects models with standard mean differences and risk ratios for continuous and dichotomous variables, respectively. Subgroup analysis was performed according to the IV or intraarticular administration of TXA.

resultsThirty-four RCTs encompassing 2,594 patients met the inclusion criteria for our meta-analysis. Our meta-analysis indicated that when compared with the control group, the IV or intraarticular use of TXA significantly reduced total blood loss, postoperative blood loss, Hb loss, and transfusion rate as well as blood units transfused per patient after primary TKA, but did not reduce intraoperative blood loss. No significant difference in deep vein thrombosis (DVT), pulmonary embolism, or other adverse events among the study groups.

conclusionsIV or intraarticular use of TXA for patients undergoing TKA is effective and safe for the reduction blood loss and blood transfusion requirements, yet does not increase the risk of postoperative DVT. LEVEL OF EVIDENCE: Level II.

Indexed as

Administration, IntravenousAntifibrinolytic AgentsArthroplasty, Replacement, KneeBlood Loss, SurgicalBlood TransfusionHemoglobinsHumansInjections, Intra-ArticularPostoperative HemorrhageRandomized Controlled Trials as TopicTranexamic AcidAntifibrinolytic AgentsHemoglobinsTranexamic Acid

Identifiers

PMID25430635
OpenAlexW2147572453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.