ArticleEuropean journal of immunology2015
Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.
Article in European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- CARD9 Signaling, Inflammation, and Diseases.Frontiers in immunology · 2022Review
- Article
- The Role of CARD9 in Metabolic Diseases.Current medical science · 2020Review
- Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses.Molecules and cells · 2020Article
- A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma.Allergy, asthma & immunology research · 2019Article
- Article
- Human CARD9: A Critical Molecule of Fungal Immune Surveillance.Frontiers in immunology · 2018Review
- Establishment and Characterization of a Functionally Competent Type 2 Conventional Dendritic Cell Line.Frontiers in immunology · 2018Article
- A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis.PLoS neglected tropical diseases · 2017Article
- U-Omp19 fromFrontiers in immunology · 2017Article
- Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production.European journal of immunology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Toll-like receptors (TLRs) can recognize microbial patterns and utilize adaptor molecules, such as-MyD88 or (TRIF TIR-domain-containing adapter-inducing interferon-β), to initiate downstream signaling that ultimately affects the initiation of adaptive immunity. In addition to this inflammatory role, TLR5 expression on dendritic cells can favor antigen presentation of flagellin peptides and thus increase the sensitivity of flagellin-specific T-cell responses in vitro and in vivo. Here, we examined the role of alternative signaling pathways that might regulate flagellin antigen presentation in addition to MyD88. These studies suggest a requirement for spleen tyrosine kinase, a noncanonical TLR-signaling adaptor molecule, and its downstream molecule CARD9 in regulating the sensitivity of flagellin-specific CD4(+) T-cell responses in vitro and in vivo. Thus, a previously unappreciated signaling pathway plays an important role in regulating the dominance of flagellin-specific T-cell responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.