ArticleMedical science monitor : international medical journal of experimental and clinical research2014
Intra-articular adhesion reduction after knee surgery in rabbits by calcium channel blockers.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Intra-articular injection of mitomycin C prevents progression of immobilization-induced arthrogenic contracture in the remobilized rat knee.Physiological research · 2020Article
- Prospective application of stem cells to prevent post-operative skeletal fibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- The Topical Application of Rosuvastatin in Preventing Knee Intra-Articular Adhesion in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- All-trans retinoic Acid reduces joint adhesion formation: an experimental study in rats.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Effects of rapamycin on reduction of peridural fibrosis: an experimental study.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntra-articular adhesion post knee surgery is a common and serious complication. It is a challenge problem for orthopedic surgeon. Verapamil (VP), a widely applied calcium channel blocker, has been proved to be able to prevent synthesis/secretion of extracellular matrix molecules. The object of this study was to investigate the effects of VP on the prevention of joint adhesion in post-surgery rabbits. MATERIAL/
methodsA controlled double-blinded study was conducted in 40 healthy New Zealand white rabbits divided randomly into 4 groups according to the treatment method, with 10 in each group: 1) 1 mg/ml VP treatment group; 2) 2.5 mg/ml VP treatment group; 3) 5 mg/ml VP treatment group; 4) control group. Rabbits underwent surgery through the medial parapatellar approach and both lateral sides and the medial of the femoral condyle were surgically exposed. After treatment, the surgical limbs were subjected to extra-articular knee-joint immobilization in the full flexed position employing Kirschner wires for 4 weeks.
resultsThe knee surgery was successfully performed on all rabbits. The rabbits were killed 4 weeks post-operatively. The histological evaluation, hydroxyproline content, visual score, fibroblasts density, and vimentin expressional levels were conducted to assess the effect of VP on preventing joint adhesion.
conclusionsIn our rabbit model of knee surgery, intra-articular application of VP was able to decrease intra-articular adhesion formation after surgery. VP could prevent rabbit intra-articular adhesion in a dose-dependent manner and the highest concentration used in the study (5 mg/ml) proved to be the most effective.
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